159751-62-9Relevant articles and documents
Synthetic study on oscillatoxin D: Construction of the C1-C26 spiroether segment by intramolecular aldol condensation and Michael-type addition
Toshima, Hiroaki,Goto, Takashi,Ichihara, Akitami
, p. 4361 - 4364 (2007/10/02)
The C1-C7 segment (10) and the C8-C21 segment (14) of oscillatoxin D have been synthesized efficiently. The acyclic compound obtained by coupling of these two segments, has been converted into the C1-C26 spiroether (18) possessing the same stereogenic centers of oscillatoxin D. The construction of the spiroether has been achieved by intramolecular aldol condensation and Michael-type addition as key steps.