1H-1,2,4-Triazole-1-acetic acid, 2-[(2-chlorophenyl)methylene]hydrazide

Base Information

Chemical Name:1H-1,2,4-Triazole-1-acetic acid, 2-[(2-chlorophenyl)methylene]hydrazide
CAS No.:303019-73-0
Molecular Formula:C₁₁H₁₀ClN₅O
Molecular Weight:263.686
Hs Code.:
DSSTox Substance ID:DTXSID401151363

Synonyms:DTXSID401151363;HMS2791E23;303019-73-0;AKOS030747813;1H-1,2,4-Triazole-1-acetic acid, 2-[(2-chlorophenyl)methylene]hydrazide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-1,2,4-Triazole-1-acetic acid, 2-[(2-chlorophenyl)methylene]hydrazide

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:263.0573877
Heavy Atom Count:18
Complexity:312

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C=NNC(=O)CN2C=NC=N2)Cl

Technology Process of 1H-1,2,4-Triazole-1-acetic acid, 2-[(2-chlorophenyl)methylene]hydrazide

There total 1 articles about 1H-1,2,4-Triazole-1-acetic acid, 2-[(2-chlorophenyl)methylene]hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 89-98-5
2-chloro-benzaldehyde

: 56563-02-1
2-(1H-1,2,4-triazol-1-yl)acetohydrazide

: 303019-73-0
[1,2,4]Triazol-1-yl-acetic acid [1-(2-chloro-phenyl)-meth-(E)-ylidene]-hydrazide

Guidance literature:: With acetic acid; In chloroform; Heating;

Reference yield: 83.0%

: 68-11-1
mercaptoacetic acid

: 303019-73-0
[1,2,4]Triazol-1-yl-acetic acid [1-(2-chloro-phenyl)-meth-(E)-ylidene]-hydrazide

: N-[2-(2-chloro-phenyl)-4-oxo-thiazolidin-3-yl]-2-[1,2,4]triazol-1-yl-acetamide

Guidance literature:: With zinc(II) chloride; In tetrahydrofuran; Heating;

Reference yield:

: 303019-73-0
[1,2,4]Triazol-1-yl-acetic acid [1-(2-chloro-phenyl)-meth-(E)-ylidene]-hydrazide

: N-{2-(2-Chloro-phenyl)-5-[1-(2-chloro-phenyl)-meth-(Z)-ylidene]-4-oxo-thiazolidin-3-yl}-2-[1,2,4]triazol-1-yl-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / ZnCl₂ / tetrahydrofuran / Heating

2: 78 percent / EtONa / dioxane / Heating

With sodium ethanolate; zinc(II) chloride; In tetrahydrofuran; 1,4-dioxane; 2: Knoevenagel reaction;