56563-02-1

Basic information

• Product Name: 2-(1H-1,2,4-TRIAZOL-1-YL)ACETOHYDRAZIDE
• Synonyms: 2-(1H-1,2,4-TRIAZOL-1-YL)ACETOHYDRAZIDE
• CAS NO: 56563-02-1
• Molecular Formula: C₄H₇N₅O
• Molecular Weight: 141.13
• Mol File: 56563-02-1.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(1H-1,2,4-TRIAZOL-1-YL)ACETOHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1H-1,2,4-TRIAZOL-1-YL)ACETOHYDRAZIDE(56563-02-1)
• EPA Substance Registry System: 2-(1H-1,2,4-TRIAZOL-1-YL)ACETOHYDRAZIDE(56563-02-1)

Safety Data

• Hazardous Substances Data: 56563-02-1(Hazardous Substances Data)

Usage

Type of compound

a chemical compound and reagent

Uses

intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds

Derivative

hydrazide derivative of 1,2,4-triazole

Potential role

chelating ligand in coordination chemistry

Bioactivity

used in the preparation of bioactive compounds, including potential anti-tuberculosis agents

Antimicrobial properties

studied for its potential as an antimicrobial and antifungal agent

Versatility

versatile compound with diverse applications in chemical and pharmaceutical research.

Upstream product

• 56563-01-0 ethyl 2-(1H-1,2,4-triazol-1-yl)acetate 

Downstream Products

• 28711-29-7 2-(1H-1,2,4-triazol-1-yl)acetic acid 
• 26911-66-0 2-hydroxy-5,7-dimethylpyrazolo(1,5-a)-pyrimidine 
• 22114-32-5 4,6-Dimethyl-2-pyrimidinylacetic acid ethyl ester 
• 1083067-80-4 4-benzoyl-1-[(1,2,4-triazol-1-yl)acetyl]semicarbazide 
• 1083067-81-5 4-benzenesulfonyl-1-[(1,2,4-triazol-1-yl)acetyl]semicarbazide 
• 1083067-78-0 4-(4-ethoxyphenyl)-1-[(1,2,4-triazol-1-yl)acetyl]semicarbazide 
• 1083067-77-9 4-benzyl-1-[(1,2,4-triazol-1-yl)acetyl]semicarbazide 
• 1083067-75-7 4-cyclohexyl-1-[(1,2,4-triazol-1-yl)acetyl]semicarbazide 
• 1083067-73-5 4-phenyl-1-[(1,2,4-triazol-1-yl)acetyl]semicarbazide 
• 342596-85-4 [1,2,4]Triazol-1-yl-acetic acid [1-(3-bromo-phenyl)-meth-(E)-ylidene]-hydrazide 
• 496811-47-3 [1,2,4]Triazol-1-yl-acetic acid [1-(2-nitro-phenyl)-meth-(E)-ylidene]-hydrazide 
• 356780-33-1 [1,2,4]Triazol-1-yl-acetic acid [1-(2-bromo-phenyl)-meth-(E)-ylidene]-hydrazide 
• 343357-22-2 [1,2,4]Triazol-1-yl-acetic acid [1-(2-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide 
• 342032-47-7 [1,2,4]Triazol-1-yl-acetic acid [1-(3-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide 

Relevant articles and documents

7-OXO -6-(SULFOOXY)- 1,6-DIAZABICYCLO [3.2.1] OCTANE CONTAINING COMPOUNDS AND THEIR USE IN TREATMENT OF BACTERIAL INFECTIONS

Compounds of Formula (I) or a stereoisomer or a pharmaceutically acceptable salt thereof, their preparation, and use in treating a bacterial infection are disclosed.

Synthesis, experimental and theoretical study on the structure of some semicarbazides with potential antibacterial activity

A series of 1,4-disubstituted semicarbazide and 4,4'-bis[1-substituted semicarbazide]diphenyl-methane derivatives were synthesized to explore their antibacterial activity. New compounds were characterized by elemental analysis and spectroscopic data. In order to find the tautomeric equilibrium for the molecules energy calculations for each possible tautomeric form of model compound 2, and for the most antibacterially active compound 7 in the investigated series, were calculated for the gas phase at the RHF/SCF/6-31G** level of theory.

Synthesis and structure of mono- and disubstituted derivatives of 4,5-dihydro-1H-1,2,4-triazol-5-one

In the reaction of hydrazide of 1,2,4-triazol-1-acetic acid with isocyanates the semi-carbazide derivatives were obtained (Ia-Ii). Depending on the chemical nature of the starting isocyanate, cyclization of Ia-Ii in alkaline medium led to formation of three groups of derivatives of 4,5-dihydro-1H-1,2,4- triazol-5-one (IIa-IIi). Alkyl and aryl substituents of semicarbazides formed 3,4-disubstituted compounds (IIa-IIf), the ethoxycarbonyl group promoted formation of 3-substituted compound IIg, while compounds IIh and IIi are 4-substituted triazol-5-ones resulting from benzoyl and benzenesulfonyl isocyanates. Molecular structures of three products (IIb, IIc, IId) were confirmed by the X-ray structure analysis. Different substituents at the N4 atom (ethyl in IIb, cyclohexyl in IIc and 1-naphthyl in IId) influence the molecular association pattern in the crystal structure.