2-chloro-N'-(2-(2-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)acetyl)acetohydrazide

Base Information

• Chemical Name: 2-chloro-N'-(2-(2-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)acetyl)acetohydrazide
• CAS No.: 1309588-11-1
• Molecular Formula: C₂₄H₂₈ClN₅O₂S
• Molecular Weight: 486.038
• Mol file: 1309588-11-1.mol

Synonyms:2-chloro-N'-(2-(2-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)acetyl)acetohydrazide

Chemical Property of 2-chloro-N'-(2-(2-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)acetyl)acetohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-N'-(2-(2-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)acetyl)acetohydrazide

There total 5 articles about 2-chloro-N'-(2-(2-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)acetyl)acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-(2-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)acetohydrazide (1309588-10-0) + chloroacetyl chloride (79-04-9) → 2-chloro-N'-(2-(2-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)acetyl)acetohydrazide (1309588-11-1)

Guidance literature:

With triethylamine; In benzene; for 10h; Reflux;

DOI:10.1007/s00044-010-9389-z

Reference yield:

2-(2-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)acetic acid (1309588-07-5) → 2-chloro-N'-(2-(2-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)acetyl)acetohydrazide (1309588-11-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride / 4 h / Reflux

1.2: 6 h / Reflux

2.1: triethylamine / benzene / 10 h / Reflux

With thionyl chloride; triethylamine; In benzene;

DOI:10.1007/s00044-010-9389-z

Reference yield:

ibuprofen (15687-27-1,58560-75-1) → 2-chloro-N'-(2-(2-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)acetyl)acetohydrazide (1309588-11-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: dicyclohexyl-carbodiimide / tetrahydrofuran / 5 °C

2.1: tetrahydrofuran / 12 h / Reflux

3.1: hydrogenchloride; potassium hydroxide / water / Reflux

4.1: ethanol / 4 h / Reflux

5.1: thionyl chloride / 4 h / Reflux

5.2: 6 h / Reflux

6.1: triethylamine / benzene / 10 h / Reflux

With hydrogenchloride; thionyl chloride; triethylamine; dicyclohexyl-carbodiimide; potassium hydroxide; In tetrahydrofuran; ethanol; water; benzene;

DOI:10.1007/s00044-010-9389-z

upstream raw materials:

2-(2-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)acetic acid

2-(2-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)acetohydrazide

chloroacetyl chloride

ibuprofen

Downstream raw materials:

2-(2-(2-(2-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)acetyl)hydrazinyl)-2-oxoethyl nitrate