2',3'-Dideoxy-2'-fluoroarabinofuranosyladenine

Base Information

Chemical Name:2',3'-Dideoxy-2'-fluoroarabinofuranosyladenine
CAS No.:110143-09-4
Molecular Formula:C₁₀H₁₂FN₅O₂
Molecular Weight:253.236
Hs Code.:2934999090
DSSTox Substance ID:DTXSID30149153
Nikkaji Number:J988.243J
Wikidata:Q83014842
Mol file:110143-09-4.mol

Synonyms:2',3'-dideoxy-2'-fluoro-ara-A;2',3'-dideoxy-2'-fluoro-beta-D-arabinofuranosyladenine;2',3'-dideoxy-2'-fluoroarabinofuranosyladenine;2'-fluoro-2',3'-dideoxyarabinosyl adenine;DDF-ara-A

Suppliers and Price of 2',3'-Dideoxy-2'-fluoroarabinofuranosyladenine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 2',3'-Dideoxy-2'-fluoroarabinofuranosyladenine

Chemical Property:

Boiling Point:541.3oC at 760 mmHg
Flash Point:281.2oC
PSA：99.08000
Density:1.85g/cm3
LogP:0.60760
XLogP3:0.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:253.09750280
Heavy Atom Count:18
Complexity:310

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(C(OC1N2C=NC3=C(N=CN=C32)N)CO)F
Isomeric SMILES:C1[C@H]([C@H](O[C@H]1N2C=NC3=C(N=CN=C32)N)CO)F

Technology Process of 2',3'-Dideoxy-2'-fluoroarabinofuranosyladenine

There total 4 articles about 2',3'-Dideoxy-2'-fluoroarabinofuranosyladenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110143-08-3
9-{(2R,4R,5R)-4-Fluoro-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-9H-purin-6-ylamine

: 110143-09-4
9-(3-fluoro-2,3-dideoxy-β-D-threo-pentofuranosyl)adenine

Guidance literature:: With toluene-4-sulfonic acid; In methanol; chloroform; for 0.333333h; Yield given;
DOI:10.1021/jm00394a034

Reference yield:

: 20535-16-4
(2R,3S,4R,5R)-2-(6-amino-9H-purin-9-yl)-4-fluoro-5-(hydroxymethyl)tetrahydrofuran-3-ol

: 110143-09-4
9-(3-fluoro-2,3-dideoxy-β-D-threo-pentofuranosyl)adenine

Guidance literature:: Multi-step reaction with 4 steps

1: 68 percent / pyridine / Ambient temperature

2: 92 percent / 4-(dimethylamino)pyridine / acetonitrile / Ambient temperature

3: 84 percent / tri-n-butyltin hydride, 2,2'-azobis(2-methylpropionitrile) / toluene / 0.75 h / 80 °C

4: p-toluenesulfonic acid / CHCl₃; methanol / 0.33 h

With pyridine; dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; toluene-4-sulfonic acid; In methanol; chloroform; toluene; acetonitrile;
DOI:10.1021/jm00394a034

Reference yield:

: 110143-06-1
9-[5-O-(monomethoxytrityl)-3-fluoro-3-deoxy-β-D-xylo-pentofuranosyl]adenine

: 110143-09-4
9-(3-fluoro-2,3-dideoxy-β-D-threo-pentofuranosyl)adenine

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / 4-(dimethylamino)pyridine / acetonitrile / Ambient temperature

2: 84 percent / tri-n-butyltin hydride, 2,2'-azobis(2-methylpropionitrile) / toluene / 0.75 h / 80 °C

3: p-toluenesulfonic acid / CHCl₃; methanol / 0.33 h

With dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; toluene-4-sulfonic acid; In methanol; chloroform; toluene; acetonitrile;
DOI:10.1021/jm00394a034