9-[5-O-(monomethoxytrityl)-3-fluoro-3-deoxy-β-D-xylo-pentofuranosyl]adenine

Base Information

Chemical Name:9-[5-O-(monomethoxytrityl)-3-fluoro-3-deoxy-β-D-xylo-pentofuranosyl]adenine
CAS No.:110143-06-1
Molecular Formula:C₃₀H₂₈FN₅O₄
Molecular Weight:541.582
Hs Code.:

Synonyms:9-[5-O-(monomethoxytrityl)-3-fluoro-3-deoxy-β-D-xylo-pentofuranosyl]adenine

Suppliers and Price of 9-[5-O-(monomethoxytrityl)-3-fluoro-3-deoxy-β-D-xylo-pentofuranosyl]adenine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 9-[5-O-(monomethoxytrityl)-3-fluoro-3-deoxy-β-D-xylo-pentofuranosyl]adenine

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Technology Process of 9-[5-O-(monomethoxytrityl)-3-fluoro-3-deoxy-β-D-xylo-pentofuranosyl]adenine

There total 1 articles about 9-[5-O-(monomethoxytrityl)-3-fluoro-3-deoxy-β-D-xylo-pentofuranosyl]adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 20535-16-4
(2R,3S,4R,5R)-2-(6-amino-9H-purin-9-yl)-4-fluoro-5-(hydroxymethyl)tetrahydrofuran-3-ol

: 14470-28-1
mono-4-methoxytrityl chloride

: 110143-06-1
9-[5-O-(monomethoxytrityl)-3-fluoro-3-deoxy-β-D-xylo-pentofuranosyl]adenine

Guidance literature:: With pyridine; Ambient temperature;
DOI:10.1021/jm00394a034

Reference yield: 92.0%

: 110143-06-1
9-[5-O-(monomethoxytrityl)-3-fluoro-3-deoxy-β-D-xylo-pentofuranosyl]adenine

: 1005-56-7
phenylcarbonochloridothioate

: 110143-07-2
9-[5-O-(monomethoxytrityl)-3-fluoro-3-deoxy-2-O-(phenyoxythiocarbonyl)-β-D-xylo-pentofuranosyl]adenine

Guidance literature:: With dmap; In acetonitrile; Ambient temperature;
DOI:10.1021/jm00394a034

Reference yield:

: 110143-06-1
9-[5-O-(monomethoxytrityl)-3-fluoro-3-deoxy-β-D-xylo-pentofuranosyl]adenine

: 110143-08-3
9-{(2R,4R,5R)-4-Fluoro-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-9H-purin-6-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / 4-(dimethylamino)pyridine / acetonitrile / Ambient temperature

2: 84 percent / tri-n-butyltin hydride, 2,2'-azobis(2-methylpropionitrile) / toluene / 0.75 h / 80 °C

With dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; acetonitrile;
DOI:10.1021/jm00394a034