1-benzyl 2-tert-butyl (1S)-1-phenyl-3,4-dihydroisoquinoline-1,2(1H)-dicarboxylate

Base Information

Chemical Name:1-benzyl 2-tert-butyl (1S)-1-phenyl-3,4-dihydroisoquinoline-1,2(1H)-dicarboxylate
CAS No.:1591920-36-3
Molecular Formula:C₂₈H₂₉NO₄
Molecular Weight:443.543
Hs Code.:

Synonyms:1-benzyl 2-tert-butyl (1S)-1-phenyl-3,4-dihydroisoquinoline-1,2(1H)-dicarboxylate

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Chemical Property of 1-benzyl 2-tert-butyl (1S)-1-phenyl-3,4-dihydroisoquinoline-1,2(1H)-dicarboxylate

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Technology Process of 1-benzyl 2-tert-butyl (1S)-1-phenyl-3,4-dihydroisoquinoline-1,2(1H)-dicarboxylate

There total 11 articles about 1-benzyl 2-tert-butyl (1S)-1-phenyl-3,4-dihydroisoquinoline-1,2(1H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 5532-86-5
benzyl cyanoformate

: tert-butyl (S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1591920-36-3
1-benzyl 2-tert-butyl (1S)-1-phenyl-3,4-dihydroisoquinoline-1,2(1H)-dicarboxylate

Guidance literature:: tert-butyl (S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

benzyl cyanoformate; In tetrahydrofuran; hexane; at 20 ℃; for 16h;
DOI:10.1021/ja500485f

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1591920-36-3
1-benzyl 2-tert-butyl (1S)-1-phenyl-3,4-dihydroisoquinoline-1,2(1H)-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 20 h / 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.2: 16 h / 20 °C

With n-butyllithium; In tetrahydrofuran; hexane;
DOI:10.1021/ja500485f

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1591920-36-3
1-benzyl 2-tert-butyl (1S)-1-phenyl-3,4-dihydroisoquinoline-1,2(1H)-dicarboxylate

: 1-benzyl 2-tert-butyl (1R)-1-phenyl-3,4-dihydroisoquinoline-1,2(1H)-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 20 h / 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.07 h / -50 °C

2.2: 16 h / 20 °C

3.1: Beckman system fitted with a Lux × 3u cellulose?1 (250 mm × 4.60 mm i.d.) / hexane; isopropyl alcohol / Resolution of racemate

With n-butyllithium; In tetrahydrofuran; hexane; isopropyl alcohol;
DOI:10.1021/ja500485f