5532-86-5

Usage

Uses

Used in Pharmaceutical Industry:
Benzyl cyanoformate is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its versatility in undergoing different chemical reactions allows for the creation of complex organic molecules that are essential in developing new drugs and improving existing ones.
Used in Agrochemical Industry:
In the agrochemical sector, benzyl cyanoformate is utilized as an intermediate for the production of various agrochemicals. Its reactivity in chemical reactions contributes to the development of effective and innovative products for agricultural applications.
Used in Fine Chemicals Industry:
Benzyl cyanoformate is employed as a versatile reagent in the synthesis of fine chemicals. Its ability to participate in esterification, amidation, and cyclization reactions makes it an indispensable component in the production of specialty chemicals with specific applications in various industries.
Used in Research and Development:
Benzyl cyanoformate is used as a building block in the research and development of new chemical compounds. Its potential for various chemical reactions makes it a valuable tool for scientists and researchers in exploring novel synthetic pathways and creating innovative products.

InChI:InChI=1/C9H7NO2/c10-6-9(11)12-7-8-4-2-1-3-5-8/h1-5H,7H2

Upstream product

• 143-33-9 sodium cyanide 
• 501-53-1 benzyl chloroformate 
• 151-50-8 potassium cyanide 
• 1115-12-4 carbonyl cyanide 
• 100-51-6 benzyl alcohol 
• 280-57-9 1,4-diaza-bicyclo[2.2.2]octane 
• 7677-24-9 trimethylsilyl cyanide 
• 5396-89-4 benzyl acetoacetate 
• 15014-25-2 malonic acid dibenzyl ester 
• 51118-40-2 dibenzyl 2-(hydroxyimino)malonate 
• 27331-98-2 benzyl (Z/E)-2-hydroxyimino-3-oxobutanoate 

Downstream Products

• 128365-00-4 2-benzyl-5-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)tetrazole 
• 128365-07-1 1-benzyl-5-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)tetrazole 
• 28386-90-5 5-benzyl-1-phenyl-1H-tetrazole 
• 28386-89-2 2-benzyl-5-phenyl-2H-tetrazole 
• 89965-56-0 <3-<<4-(carboxyamino)butyl>amino>propyl>carbamic acid, dibenzyl ester 
• 14468-80-5 N-benzyloxycarbonylpyrrolidin-2-one 
• 183249-68-5 [3-(3-benzyloxycarbonylaminopropylamino)propyl]carbamic acid benzyl ester 
• 177533-25-4 (Methoxy-phenyl-phosphinoyl)-(4-nitro-phenyl)-acetic acid benzyl ester 
• 188633-58-1 C₂₀H₂₃NO₅S 
• 246164-19-2 benzyl 2-amino-3-ethoxycarbonyl-4-oxo-4-(2',3',5'-tri-O-benzoyl-β-D-ribofuranosyl)-2-butenoate 
• 493009-88-4 benzyl 5,5-diethoxypentylcarbamate 
• 568589-93-5 N,N'-di(benzyloxycarbonyl)-3-aza-1,6-hexanediamine 
• 646064-64-4 3-benzyloxycarbonyl-3-methylchroman-4-one 
• 646064-68-8 3-benzyloxycarbonyl-7-methoxy-3-methylchroman-4-one 

Relevant academic research and scientific papers

An expedient synthesis of cyanoformates via DAST-mediated C–C bond cleavage of α-oximino-β-ketoesters

A new protocol to synthesize cyanoformates was developed using simple β-ketoesters as substrates. (Diethylamino)sulfur trifluoride (DAST) was used as a dual-role reagent to activate the oxime moiety and to donate a fluoride. The key intermediates, α-oximino-β-ketoesters, were prepared by highly efficient acid-assisted oximation of β-ketoesters. Then, the deconstruction of α-oximino-β-ketoesters by the fluorinative C–C bond cleavage was demonstrated to provide cyanoformates. In this event, the fluoride addition followed by the C–C bond cleavage selectively occurred in the ketones over esters. Due to simple and mild reaction conditions, variously functionalized cyanoformates were exemplified.

HETEROARYL DERIVATIVES AS SEPIAPTERIN REDUCTASE INHIBITORS

Inhibitors of sepiapterin reductase of formula (I) or (I'), wherein the substituents are defined as in the claims, and uses of sepiapterin reductase inhibitors in analgesia, treatment of acute and chronic pain, anti-inflammation, and immune cell regulation are disclosed.

Process for producing cyanoformate esters

Alkyl, aralkyl or aryl cyanoformate esters having from one to 20 carbon atoms are prepared by anhydrously reacting stoichiometric amounts of the corresponding alkyl, aralkyl or aryl haloformate and an organosilyl nitrile in the presence of a catalytic amount of a tertiary amine base, preferably 1,4-diazabicyclo?2.2.2!octane, in the absence or presence of an inert solvent. The reaction is conducted at a temperature of from about -30° C. to 70° C., preferably at from about 5° C. to 30° C.