4-(2,4-dichloro-phenyl)-1-methyl-1H-pyrrole-3-carboxylic acid methyl-naphthalen-1-ylmethyl-amide

Base Information

Chemical Name:4-(2,4-dichloro-phenyl)-1-methyl-1H-pyrrole-3-carboxylic acid methyl-naphthalen-1-ylmethyl-amide
CAS No.:191667-75-1
Molecular Formula:C₂₄H₂₀Cl₂N₂O
Molecular Weight:423.342
Hs Code.:

4-(2,4-dichloro-phenyl)-1-methyl-1<i>H</i>-pyrrole-3-carboxylic acid methyl-naphthalen-1-ylmethyl-amide

Synonyms:4-(2,4-dichloro-phenyl)-1-methyl-1H-pyrrole-3-carboxylic acid methyl-naphthalen-1-ylmethyl-amide

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Chemical Property of 4-(2,4-dichloro-phenyl)-1-methyl-1H-pyrrole-3-carboxylic acid methyl-naphthalen-1-ylmethyl-amide

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Technology Process of 4-(2,4-dichloro-phenyl)-1-methyl-1H-pyrrole-3-carboxylic acid methyl-naphthalen-1-ylmethyl-amide

There total 4 articles about 4-(2,4-dichloro-phenyl)-1-methyl-1H-pyrrole-3-carboxylic acid methyl-naphthalen-1-ylmethyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 65473-13-4
N-methyl-1-naphthalenemethylamine hydrochloride

: 191668-29-8
4-(2,4-dichloro-phenyl)-1-methyl-1H-pyrrole-3-carboxylic acid

: 191667-75-1
4-(2,4-dichloro-phenyl)-1-methyl-1H-pyrrole-3-carboxylic acid methyl-naphthalen-1-ylmethyl-amide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 1504-68-3,24393-62-2
(E)-ethyl 3-(2,4-dichlorophenyl)acrylate

: 191667-75-1
4-(2,4-dichloro-phenyl)-1-methyl-1H-pyrrole-3-carboxylic acid methyl-naphthalen-1-ylmethyl-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / 60 percent sodium hydride in oil / dimethylsulfoxide; diethyl ether / 0.08 h / 20 °C

2: 99 percent / potassium carbonate / dimethylformamide / 18 h / 90 °C

3: 100 percent / aq. sodium hydroxide / aq. ethanol / 5 h / Heating

4: 82 percent / triethylamine; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 3 h / 20 °C

With sodium hydroxide; sodium hydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; 1: Cycloaddition / 2: Methylation / 3: Hydrolysis / 4: Condensation;

Reference yield:

: 191668-09-4
4-(2,4-Dichloro-phenyl)-1H-pyrrole-3-carboxylic acid ethyl ester

: 191667-75-1
4-(2,4-dichloro-phenyl)-1-methyl-1H-pyrrole-3-carboxylic acid methyl-naphthalen-1-ylmethyl-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / potassium carbonate / dimethylformamide / 18 h / 90 °C

2: 100 percent / aq. sodium hydroxide / aq. ethanol / 5 h / Heating

3: 82 percent / triethylamine; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 3 h / 20 °C

With sodium hydroxide; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide; 1: Methylation / 2: Hydrolysis / 3: Condensation;