ethyl N-{(1R,2S)-1-benzyl-2-hydroxy-3-[(4R)-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]propyl}carbamate

Base Information

Chemical Name:ethyl N-{(1R,2S)-1-benzyl-2-hydroxy-3-[(4R)-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]propyl}carbamate
CAS No.:1301767-86-1
Molecular Formula:C₂₃H₃₀N₂O₅S
Molecular Weight:446.568
Hs Code.:

Synonyms:ethyl N-{(1R,2S)-1-benzyl-2-hydroxy-3-[(4R)-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]propyl}carbamate

Suppliers and Price of ethyl N-{(1R,2S)-1-benzyl-2-hydroxy-3-[(4R)-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]propyl}carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl N-{(1R,2S)-1-benzyl-2-hydroxy-3-[(4R)-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]propyl}carbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl N-{(1R,2S)-1-benzyl-2-hydroxy-3-[(4R)-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]propyl}carbamate

There total 5 articles about ethyl N-{(1R,2S)-1-benzyl-2-hydroxy-3-[(4R)-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]propyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1301768-08-0
(4R)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutyl]-4-methyl-2,3,4,5-tetrahydro-1H-1λ6,2-benzothiazepine-1,1-dione

: 541-41-3
chloroformic acid ethyl ester

: 1301767-86-1
ethyl N-{(1R,2S)-1-benzyl-2-hydroxy-3-[(4R)-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]propyl}carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 1301767-83-8
2-{[(4S,5R)-4-benzyl-2-oxo-1,3-oxazolidin-5-yl]methyl}-2,3,4,5-tetrahydro-1H-1 λ6,2-benzothiazepine-1,1-dione

: 1301767-86-1
ethyl N-{(1R,2S)-1-benzyl-2-hydroxy-3-[(4R)-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]propyl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 3 - 4 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1301768-06-8
2-bromo-N-(2-methylallyl)benzenesulfonamide

: 1301767-86-1
ethyl N-{(1R,2S)-1-benzyl-2-hydroxy-3-[(4R)-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]propyl}carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2,2'-azobis(isobutyronitrile) / toluene / 60 - 70 °C

1.2: Inert atmosphere; Reflux

2.1: caesium carbonate / N,N-dimethyl-formamide / 10 - 12 h / 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 3 - 4 h / 20 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With 2,2'-azobis(isobutyronitrile); caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;