1-(2-(3-(4-(2-(cyclopentyloxy)ethoxy)phenoxy)-2-hydroxypropylamino)ethyl)-3-(2-hydroxyphenyl)urea

Base Information

Chemical Name:1-(2-(3-(4-(2-(cyclopentyloxy)ethoxy)phenoxy)-2-hydroxypropylamino)ethyl)-3-(2-hydroxyphenyl)urea
CAS No.:1354967-14-8
Molecular Formula:C₂₅H₃₅N₃O₆
Molecular Weight:473.569
Hs Code.:

Synonyms:1-(2-(3-(4-(2-(cyclopentyloxy)ethoxy)phenoxy)-2-hydroxypropylamino)ethyl)-3-(2-hydroxyphenyl)urea

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(2-(3-(4-(2-(cyclopentyloxy)ethoxy)phenoxy)-2-hydroxypropylamino)ethyl)-3-(2-hydroxyphenyl)urea

Chemical Property:

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Technology Process of 1-(2-(3-(4-(2-(cyclopentyloxy)ethoxy)phenoxy)-2-hydroxypropylamino)ethyl)-3-(2-hydroxyphenyl)urea

There total 6 articles about 1-(2-(3-(4-(2-(cyclopentyloxy)ethoxy)phenoxy)-2-hydroxypropylamino)ethyl)-3-(2-hydroxyphenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 86596-60-3
2-{4-[2-(cyclopentyloxy)ethoxy]phenoxymethyl}oxirane

: 1354968-35-6
1-(2-aminoethyl)-3-(2-hydroxyphenyl)urea hydrochloride

: 1354967-14-8
1-(2-(3-(4-(2-(cyclopentyloxy)ethoxy)phenoxy)-2-hydroxypropylamino)ethyl)-3-(2-hydroxyphenyl)urea

Guidance literature:: With triethylamine; In isopropyl alcohol; for 16h; Reflux;
DOI:10.1021/jm400348g

Reference yield:

: 4-(2-[cyclopentyloxy]ethoxy)phenol

: 1354967-14-8
1-(2-(3-(4-(2-(cyclopentyloxy)ethoxy)phenoxy)-2-hydroxypropylamino)ethyl)-3-(2-hydroxyphenyl)urea

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide; mineral oil / 0.33 h / 20 °C / Inert atmosphere

1.2: 7 h

2.1: triethylamine / isopropyl alcohol / 16 h / Reflux

With triethylamine; In N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;

Reference yield:

: 176-32-9
1,4-dioxaspiro[4.4]nonane

: 1354967-14-8
1-(2-(3-(4-(2-(cyclopentyloxy)ethoxy)phenoxy)-2-hydroxypropylamino)ethyl)-3-(2-hydroxyphenyl)urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: zirconium(IV) chloride; sodium tetrahydroborate / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

2.1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / dichloromethane / 20 °C

3.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h / 0 - 20 °C

4.2: 20 °C

5.1: triethylamine / isopropyl alcohol / 16 h / Reflux

With sodium tetrahydroborate; di-tert-butyl-diazodicarboxylate; palladium 10% on activated carbon; hydrogen; zirconium(IV) chloride; sodium hydride; triethylamine; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil; 2.1: |Mitsunobu Displacement;
DOI:10.1021/jm400348g