Technology Process of 2-{4-[2-(cyclopentyloxy)ethoxy]phenoxymethyl}oxirane
There total 4 articles about 2-{4-[2-(cyclopentyloxy)ethoxy]phenoxymethyl}oxirane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-(2-[cyclopentyloxy]ethoxy)phenol;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
at 20 ℃;
Inert atmosphere;
Cooling with ice;
epichlorohydrin;
In
N,N-dimethyl-formamide; mineral oil;
for 7h;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: zirconium(IV) chloride; sodium tetrahydroborate / tetrahydrofuran / 0 - 5 °C
2.1: triphenylphosphine / dichloromethane
3.1: hydrogen / palladium 10% on activated carbon / ethanol
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C / Inert atmosphere; Cooling with ice
4.2: 7 h
With
sodium tetrahydroborate; hydrogen; zirconium(IV) chloride; sodium hydride; triphenylphosphine;
palladium 10% on activated carbon;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
2.1: Mitsunobu reaction;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triphenylphosphine / dichloromethane
2.1: hydrogen / palladium 10% on activated carbon / ethanol
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C / Inert atmosphere; Cooling with ice
3.2: 7 h
With
hydrogen; sodium hydride; triphenylphosphine;
palladium 10% on activated carbon;
In
ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
1.1: Mitsunobu reaction;
![4-(2-[cyclopentyloxy]ethoxy)phenol](/Databaselist/images/loading.webp)
