3-(benzylsulfonyl)-N-[(1R)-3-cyclopropyl-1-(4-fluorophenyl)-1-(trifluoromethyl)prop-2-yn-1-yl]-L-alanine

Base Information

Chemical Name:3-(benzylsulfonyl)-N-[(1R)-3-cyclopropyl-1-(4-fluorophenyl)-1-(trifluoromethyl)prop-2-yn-1-yl]-L-alanine
CAS No.:916347-58-5
Molecular Formula:C₂₃H₂₁F₄NO₄S
Molecular Weight:483.484
Hs Code.:

Synonyms:3-(benzylsulfonyl)-N-[(1R)-3-cyclopropyl-1-(4-fluorophenyl)-1-(trifluoromethyl)prop-2-yn-1-yl]-L-alanine

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Chemical Property of 3-(benzylsulfonyl)-N-[(1R)-3-cyclopropyl-1-(4-fluorophenyl)-1-(trifluoromethyl)prop-2-yn-1-yl]-L-alanine

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Technology Process of 3-(benzylsulfonyl)-N-[(1R)-3-cyclopropyl-1-(4-fluorophenyl)-1-(trifluoromethyl)prop-2-yn-1-yl]-L-alanine

There total 7 articles about 3-(benzylsulfonyl)-N-[(1R)-3-cyclopropyl-1-(4-fluorophenyl)-1-(trifluoromethyl)prop-2-yn-1-yl]-L-alanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₂₁F₄NO₂S

: C₂₃H₂₁F₄NO₃S

: 916347-58-5
3-(benzylsulfonyl)-N-[(1R)-3-cyclopropyl-1-(4-fluorophenyl)-1-(trifluoromethyl)prop-2-yn-1-yl]-L-alanine

Guidance literature:: With Oxone; In water; acetone; for 0.75h;

Reference yield:

: C₂₃H₂₁F₄NOS

: C₂₃H₂₁F₄NO₂S

: C₂₃H₂₁F₄NO₃S

: 916347-58-5
3-(benzylsulfonyl)-N-[(1R)-3-cyclopropyl-1-(4-fluorophenyl)-1-(trifluoromethyl)prop-2-yn-1-yl]-L-alanine

Guidance literature:: C₂₃H₂₁F₄NOS; With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; tert-butyl alcohol; for 4.5h;

With sodium hydroxide; In water; Alkaline aqueous solution;

With hydrogenchloride; In water; pH=4;

Reference yield:

: 655-32-3
2,2,2-trifluoro-1-(4-fluorophenyl)ethanone

: 916347-58-5
3-(benzylsulfonyl)-N-[(1R)-3-cyclopropyl-1-(4-fluorophenyl)-1-(trifluoromethyl)prop-2-yn-1-yl]-L-alanine

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridinium p-toluenesulfonate; toluene-4-sulfonic acid / toluene / 72 h / Heating / reflux

2.1: n-butyllithium / tetrahydrofuran; hexanes; toluene / 0.25 h / -78 - 0 °C

2.2: 3 h / -78 - 20 °C

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 °C

3.2: 0.33 h / -78 - 20 °C

4.1: sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 4.5 h

4.2: Alkaline aqueous solution

4.3: pH 4

With sodium chlorite; sodium dihydrogenphosphate; n-butyllithium; 2-methyl-but-2-ene; oxalyl dichloride; dimethyl sulfoxide; pyridinium p-toluenesulfonate; toluene-4-sulfonic acid; In tetrahydrofuran; hexanes; dichloromethane; water; toluene; tert-butyl alcohol;