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655-32-3

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655-32-3 Usage

Description

2,2,2,4'-TETRAFLUOROACETOPHENONE is an organic compound characterized by the presence of four fluorine atoms and an acetophenone group. It is known for its unique chemical properties and reactivity, making it a valuable intermediate in the synthesis of various pharmaceuticals and agrochemicals.

Uses

Used in Pharmaceutical Industry:
2,2,2,4'-TETRAFLUOROACETOPHENONE is used as a key intermediate in the stereoselective synthesis of trifluoromethyl-substituted 2H-furan-amines. These compounds are of significant interest due to their potential applications as pharmaceutical agents, particularly in the development of new drugs with improved therapeutic properties.
Used in Agrochemical Industry:
2,2,2,4'-TETRAFLUOROACETOPHENONE is also utilized as a building block in the synthesis of agrochemicals, such as insecticides and herbicides. The introduction of the trifluoromethyl group into these molecules can enhance their biological activity and selectivity, leading to more effective and environmentally friendly products.

Check Digit Verification of cas no

The CAS Registry Mumber 655-32-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,5 and 5 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 655-32:
(5*6)+(4*5)+(3*5)+(2*3)+(1*2)=73
73 % 10 = 3
So 655-32-3 is a valid CAS Registry Number.

655-32-3 Well-known Company Product Price

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  • Aldrich

  • (402478)  2,2,2,4′-Tetrafluoroacetophenone  99%

  • 655-32-3

  • 402478-1G

  • 380.25CNY

  • Detail
  • Aldrich

  • (402478)  2,2,2,4′-Tetrafluoroacetophenone  99%

  • 655-32-3

  • 402478-10G

  • 1,900.08CNY

  • Detail

655-32-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,2,2,4'-Tetrafluoroacetophenone

1.2 Other means of identification

Product number -
Other names 2,2,2,4'-TETRAFLUOROACETOPHENONE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:655-32-3 SDS

655-32-3Relevant articles and documents

Highly enantioselective construction of CF3-bearing all-carbon quaternary stereocenters: Hiral spiro-fused bisoxazoline ligands with 1,1′-binaphthyl sidearm for asymmetric Michael-type Friedel-Crafts reaction

Bao, Robert Li-Yuan,Fu, Kang,Shi, Lei

, (2021/11/27)

A novel class of chiral spiro-fused bisoxazoline ligands possessing a deep chiral pocket was prepared. The developed ligands have been employed in the nickel-catalyzed highly enantioselective Michael-type Friedel-Crafts reaction, affording the products bearing a trifluoromethylated all-carbon quaternary stereocenter with moderate to excellent yields (up to 99%) and good to excellent enantioselectivies (up to > 99.9% ee). Moreover, a proposed model of chiral pocket revealed that the attack of indole from the Re-face of β-CF3-β-disubstituted nitroalkene was favorable.

Visible light-promoted umpolung coupling of aryl tri-/difluoroethanones with 2-alkenylpyridines

Xu, Xiao,Min, Qing-Qiang,Li, Na,Liu, Feng

, p. 11017 - 11020 (2018/10/08)

Tertiary alcohols bearing a trifluoromethyl group are of considerable medicinal interest. Using an umpolung strategy, we herein report the first intermolecular reductive cross-coupling of aryl tri-/difluoroethanones with 2-alkenylpyridines with the aid of a Br?nsted acid catalyst upon visible-light irradiation. This metal-free reaction is operationally simple and performed at ambient temperature, allowing access to desired tertiary alcohols with tri-/difluoromethyl groups in moderate to excellent yields. The commercially available and easily handled Hantzsch ester effectively serves as an electron donor, as well as a hydrogen atom source.

Palladium-catalyzed carbonylative coupling of aryl iodides with an organocopper reagent: A straightforward procedure for the synthesis of aryl trifluoromethyl ketones

Zhu, Fengxiang,Yang, Guangfu,Zhou, Shaolin,Wu, Xiao-Feng

, p. 57070 - 57074 (2016/07/07)

A palladium-catalyzed carbonylative coupling of aryl iodides with a (trifluoromethyl)copper reagent has been developed. A wide range of substrates have been transformed into their corresponding trifluoromethyl ketones in good to excellent yields under mild conditions with high efficiency and excellent functional-group compatibility. Preliminary mechanistic investigations suggest that the transmetallation of an acylpalladium intermediate with the (trifluoromethyl)copper reagent seems to be involved in the catalytic cycle. Notably, this report represents one of the few studies on carbonylative coupling with organocopper reagents.

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