(E)-5-(2,2-diphenylcyclopropyl)-4-pentenoic acid 2-thioxo-2H-pyridin-1-yl ester

Base Information

Chemical Name:(E)-5-(2,2-diphenylcyclopropyl)-4-pentenoic acid 2-thioxo-2H-pyridin-1-yl ester
CAS No.:228860-06-8
Molecular Formula:C₂₅H₂₃NO₂S
Molecular Weight:401.529
Hs Code.:

Synonyms:(E)-5-(2,2-diphenylcyclopropyl)-4-pentenoic acid 2-thioxo-2H-pyridin-1-yl ester

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Chemical Property of (E)-5-(2,2-diphenylcyclopropyl)-4-pentenoic acid 2-thioxo-2H-pyridin-1-yl ester

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Technology Process of (E)-5-(2,2-diphenylcyclopropyl)-4-pentenoic acid 2-thioxo-2H-pyridin-1-yl ester

There total 5 articles about (E)-5-(2,2-diphenylcyclopropyl)-4-pentenoic acid 2-thioxo-2H-pyridin-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 3811-73-2
2-mercaptopyridine-1-oxide sodium salt

: (E)-5-(2,2-Diphenyl-cyclopropyl)-pent-4-enoyl chloride

: 228860-06-8
(E)-5-(2,2-diphenylcyclopropyl)-4-pentenoic acid 2-thioxo-2H-pyridin-1-yl ester

Guidance literature:: With dmap; In benzene; for 2h;
DOI:10.1021/jo990129v

Reference yield:

: 59591-01-4
2,2-diphenylcyclopropanecarbaldehyde

: 228860-06-8
(E)-5-(2,2-diphenylcyclopropyl)-4-pentenoic acid 2-thioxo-2H-pyridin-1-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) n-BuLi, hexamethyldisilazane / 1.) THF, hexane, 0 deg C, 1.5 h, 2.) THF, hexane, 0 deg C, 3 h

2: LAH / diethyl ether / 2 h

3: 40 percent / Jones reagent / acetone / 0.08 h / 0 °C

4: oxalyl chloride, DMF / benzene / 0.5 h

5: 55 percent / DMAP / benzene / 2 h

With dmap; lithium aluminium tetrahydride; n-butyllithium; jones reagent; oxalyl dichloride; N,N-dimethyl-formamide; 1,1,1,3,3,3-hexamethyl-disilazane; In diethyl ether; acetone; benzene;
DOI:10.1021/jo990129v

Reference yield:

: 228860-02-4
(E)-5-(2,2-diphenylcyclopropyl)-4-penten-1-ol

: 228860-06-8
(E)-5-(2,2-diphenylcyclopropyl)-4-pentenoic acid 2-thioxo-2H-pyridin-1-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 40 percent / Jones reagent / acetone / 0.08 h / 0 °C

2: oxalyl chloride, DMF / benzene / 0.5 h

3: 55 percent / DMAP / benzene / 2 h

With dmap; jones reagent; oxalyl dichloride; N,N-dimethyl-formamide; In acetone; benzene;
DOI:10.1021/jo990129v