3811-73-2 Usage
Description
Sodium pyrithione is mainly used for anti-mildew and antibacterial products in the fields of daily chemicals (shampoo and hair care products), architectural coatings, adhesives, sealants, pesticides, textiles, leather products, metal working fluids, etc. It can also be formulated for disinfection agents, detergents and medical broad-spectrum antifungal dermatological products. At the same time, it is also an effective fungicide and an excellent common disinfectant for fruit trees, peanuts, wheat, vegetables and other crops. Its derivative product, zinc pyrithione, is also a commonly used fungicide for daily chemicals.
Chemical Properties
sodium pyrithione belongs to pyridine derivatives fungicide, appearance is yellow full light dumpling transparent liquid, melting point 250 ℃, slightly characteristic odor. Soluble in water and ethanol and other organic solvents, solubility (by mass fraction): water 53%, ethanol 19%, polyethylene glycol (PECG400) 12%. Best use pH range 7 to 10, mass fraction of 2% aqueous solution pH 8.0. Unstable to light, oxidizing agents and strong reducing agents. Non-ionic surfactants will deactivate it somewhat, and it can chelate with heavy metals.
Uses
Different sources of media describe the Uses of 3811-73-2 differently. You can refer to the following data:
1. sodium pyrithione is a preservative that is not commonly used because of some level of toxicity. It is prohibited in Canada, and it is on the eu Annex II list of substances that must not form part of a cosmetic product composition.
2. Sodium omadine is a bactericide for use in cooling fluids and short-term in-can preservation of vinyl acetate latex, paints, and synthetic-fiber
lubricants; preservative for cosmetic rinse-off products.
Definition
Apparently exists in equilibrium with the -SH form. Forms chelates with iron, manganese, zinc, etc.
Application
2-Mercaptopyridine N-oxide sodium salt is one of the active components in paint, sealants, shampoo, adhesive and aerosol due to its anti-microbial activity. In biochemistry studies, it is utilized to transport zinc into cells. Further, it is used to form bidentate oxothiolane chelates with transition metals. It acts as a stabilizer and viscosity building provider in weak basic or neutral medium.
General Description
2-Mercaptopyridine N-oxide acts as labelling agent during indium-111 labelling of human platelets. It acts as bioactive ligand and forms palladium and platinum complexes, which were tested as potential antitrypanosomal agents.
Biochem/physiol Actions
2-Mercaptopyridine N-oxide is a zinc ionophore that transports zinc into cells.
Safety Profile
Poison by
intraperitoneal and intravenous routes.
Moderately toxic by ingestion, subcutaneous
and parenteral routes. Used in preservation
of cosmetics. When heated to
decomposition it emits very toxic fumes of
Na2O, NOx, and SOx. See also
MERCAPTANS.
Purification Methods
When recrystallised from water, it assayed as 98.7% based on AgNO3 titration [Krivis et al. Anal Chem 35 966 1963; see also Krivis et al. Anal Chem 48 1001 1976, and Barton & Crich J Chem Soc, Perkin Trans 1 1603, 1613 1986]. [Beilstein 21/7 V 151.]
Mode of action
Pyrithione Sodium is the sodium salt form of pyrithione, a fungistatic and antimicrobial derivative of aspergillic acid. Although the exact mechanism of action remains to be fully elucidated, pyrithione sodium appears to interfere with membrane transport ultimately leading to a loss of metabolic control.
Check Digit Verification of cas no
The CAS Registry Mumber 3811-73-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,8,1 and 1 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 3811-73:
(6*3)+(5*8)+(4*1)+(3*1)+(2*7)+(1*3)=82
82 % 10 = 2
So 3811-73-2 is a valid CAS Registry Number.
InChI:InChI=1/C5H5NOS.Na/c7-6-4-2-1-3-5(6)8;/h1-4,8H;/q;+1
3811-73-2Relevant articles and documents
Recyclable anhydride catalyst for H2O2 oxidation:: N -oxidation of pyridine derivatives
Gajeles, Ghellyn,Kim, Se Mi,Lee, Kyung-Koo,Lee, Sang Hee,Yoo, Jong-Cheol
, p. 9165 - 9171 (2020/03/13)
The catalytic efficiency and recyclability of poly(maleic anhydride-alt-1-octadecene) (Od-MA) and poly(maleic anhydride-alt-1-isobutylene) (Bu-MA) were evaluated for use in the development of a metal-free, reusable catalyst for the oxidation of pyridines to pyridine N-oxides in the presence of H2O2. The Od-MA catalyst was easily recovered via filtration with recovery yields exceeding 99.8%. The catalyst retained its activity after multiple uses and did not require any treatment for reuse. The Od-MA and H2O2 catalytic system described herein is eco-friendly, operationally simple, and cost-effective; thus, it is industrially applicable. Od-MA and H2O2 could potentially be used in place of percarboxylic acid as an oxidant in a wide range of oxidation reactions.
A high-quality zinc pyrithione synthetic method (by machine translation)
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Paragraph 0028; 0031; 0032, (2018/09/11)
The invention discloses a high-quality zinc pyrithione synthetic method, in order to 2 - chloro pyridine as raw materials, through catalytic oxidation, then the thiolation reaction to obtain the pyridine sulfur [...] solution; pyridine sulfur [...] solution by reduced pressure distillation, separating out the sodium chloride solid salt; thermal insulation filtering, to obtain the pyridine sulfur [...] filtrate, - 10 - 10 °C low-temperature crystallization; filtering, to obtain the pyridine sulfur [...] solid and containing pyridine sulfur [...] filtrate, filtrate circulation process for preparing pyridine sulfur [...] solid; pyridine sulfur [...] solid preparation into the pyridine sulfur [...] solution with the water-soluble zinc salt reaction to obtain the zinc pyrithione product. The method of the invention the process is simple, easy to operate, the prepared product has high purity, the whiteness is good good stability; at the same time the synthesis process has reduced the three waste generation, environmental protection, and is favorable for industrial production. (by machine translation)
Process for Preparing Alkali Metal Pyrithione and its Polyvalent Metal Complexes from Pyridine Oxide
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Paragraph 0046-0047, (2013/10/08)
The present invention generally relates to a novel process for preparing alkali metal pyrithione from pyridine N-oxide, using a sulfurination agent and a base agent. In particular, the present invention relates to an efficient process for preparing polyvalent metal complexes of sodium pyrithione from the alkali metal pyridine N-oxide described herein.
