2-tert-butyl-1,3-((3-N-benzoyloxy-3-N-(2-trans-octenoyl))propyl)diamide citrate

Base Information

• Chemical Name: 2-tert-butyl-1,3-((3-N-benzoyloxy-3-N-(2-trans-octenoyl))propyl)diamide citrate
• CAS No.: 778591-25-6
• Molecular Formula: C₄₆H₆₄N₄O₁₁
• Molecular Weight: 849.034
• Mol file: 778591-25-6.mol

Synonyms:2-tert-butyl-1,3-((3-N-benzoyloxy-3-N-(2-trans-octenoyl))propyl)diamide citrate

Chemical Property of 2-tert-butyl-1,3-((3-N-benzoyloxy-3-N-(2-trans-octenoyl))propyl)diamide citrate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-tert-butyl-1,3-((3-N-benzoyloxy-3-N-(2-trans-octenoyl))propyl)diamide citrate

There total 4 articles about 2-tert-butyl-1,3-((3-N-benzoyloxy-3-N-(2-trans-octenoyl))propyl)diamide citrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

(E)-oct-2-enoic acid chloride (100808-08-0) + tert-butyl 4-((3-((benzoyloxy)amino)propyl)amino)-2-(2-((3-((benzoyloxy)amino)propyl)amino)-2-oxoethyl)-2-hydroxy-4-oxobutanoate (778591-23-4) → 2-tert-butyl-1,3-((3-N-benzoyloxy-3-N-(2-trans-octenoyl))propyl)diamide citrate (778591-25-6)

Guidance literature:

In dichloromethane; for 1h; Heating;

DOI:10.1021/ja048145j

Reference yield:

2-tert-butyl-1,3-di-N-(hydroxyl) succinimidyl citrate (114340-53-3) → 2-tert-butyl-1,3-((3-N-benzoyloxy-3-N-(2-trans-octenoyl))propyl)diamide citrate (778591-25-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / triethylamine / acetonitrile / 1 h / 25 °C

2: 77 percent / CH₂Cl₂ / 1 h / Heating

With triethylamine; In dichloromethane; acetonitrile;

DOI:10.1021/ja048145j

Reference yield:

Nα-benzoyloxy-3-(tert-butoxycarbonylamino)propylamine (198217-06-0) → 2-tert-butyl-1,3-((3-N-benzoyloxy-3-N-(2-trans-octenoyl))propyl)diamide citrate (778591-25-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / HCl / diethyl ether; methanol / 1 h

2: 55 percent / triethylamine / acetonitrile / 1 h / 25 °C

3: 77 percent / CH₂Cl₂ / 1 h / Heating

With hydrogenchloride; triethylamine; In methanol; diethyl ether; dichloromethane; acetonitrile;

DOI:10.1021/ja048145j

upstream raw materials:

(E)-oct-2-enoic acid chloride

tert-butyl 4-((3-((benzoyloxy)amino)propyl)amino)-2-(2-((3-((benzoyloxy)amino)propyl)amino)-2-oxoethyl)-2-hydroxy-4-oxobutanoate

2-tert-butyl-1,3-di-N-(hydroxyl) succinimidyl citrate

N^α-benzoyloxy-3-(tert-butoxycarbonylamino)propylamine