tert-butyl 4-((3-((benzoyloxy)amino)propyl)amino)-2-(2-((3-((benzoyloxy)amino)propyl)amino)-2-oxoethyl)-2-hydroxy-4-oxobutanoate

Base Information

• Chemical Name: tert-butyl 4-((3-((benzoyloxy)amino)propyl)amino)-2-(2-((3-((benzoyloxy)amino)propyl)amino)-2-oxoethyl)-2-hydroxy-4-oxobutanoate
• CAS No.: 778591-23-4
• Molecular Formula: C₃₀H₄₀N₄O₉
• Molecular Weight: 600.669
• Mol file: 778591-23-4.mol

Synonyms:tert-butyl 4-((3-((benzoyloxy)amino)propyl)amino)-2-(2-((3-((benzoyloxy)amino)propyl)amino)-2-oxoethyl)-2-hydroxy-4-oxobutanoate

Chemical Property of tert-butyl 4-((3-((benzoyloxy)amino)propyl)amino)-2-(2-((3-((benzoyloxy)amino)propyl)amino)-2-oxoethyl)-2-hydroxy-4-oxobutanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-((3-((benzoyloxy)amino)propyl)amino)-2-(2-((3-((benzoyloxy)amino)propyl)amino)-2-oxoethyl)-2-hydroxy-4-oxobutanoate

There total 3 articles about tert-butyl 4-((3-((benzoyloxy)amino)propyl)amino)-2-(2-((3-((benzoyloxy)amino)propyl)amino)-2-oxoethyl)-2-hydroxy-4-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

2-tert-butyl-1,3-di-N-(hydroxyl) succinimidyl citrate (114340-53-3) + 1-N-benzoyloxy-1,3-diaminopropane dihydrochloride → tert-butyl 4-((3-((benzoyloxy)amino)propyl)amino)-2-(2-((3-((benzoyloxy)amino)propyl)amino)-2-oxoethyl)-2-hydroxy-4-oxobutanoate (778591-23-4)

Guidance literature:

With triethylamine; In acetonitrile; at 25 ℃; for 1h;

DOI:10.1021/ja048145j

Reference yield: 20.0%

3-(tert-butoxycarbonyl)-3-hydroxypentanedioic acid (114340-52-2) + 1-N-benzoyloxy-1,3-diaminopropane dihydrochloride → tert-butyl 4-((3-((benzoyloxy)amino)propyl)amino)-2-(2-((3-((benzoyloxy)amino)propyl)amino)-2-oxoethyl)-2-hydroxy-4-oxobutanoate (778591-23-4)

Guidance literature:

With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 40 ℃; for 0.5h; Microwave irradiation;

DOI:10.1039/c9dt02731a

Reference yield:

Nα-benzoyloxy-3-(tert-butoxycarbonylamino)propylamine (198217-06-0) → tert-butyl 4-((3-((benzoyloxy)amino)propyl)amino)-2-(2-((3-((benzoyloxy)amino)propyl)amino)-2-oxoethyl)-2-hydroxy-4-oxobutanoate (778591-23-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: HCl

2.1: HOSu; DCC / dioxane

2.2: TEA / acetonitrile

With hydrogenchloride; 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In 1,4-dioxane;

DOI:10.1016/j.bmcl.2005.05.114

upstream raw materials:

2-tert-butyl-1,3-di-N-(hydroxyl) succinimidyl citrate

3-(tert-butoxycarbonyl)-3-hydroxypentanedioic acid

N^α-benzoyloxy-3-(tert-butoxycarbonylamino)propylamine

Downstream raw materials:

2-tert-butyl-1,3-((3-N-benzoyloxy-3-N-(2-trans-octenoyl))propyl)diamide citrate

2-tert-butyl-1,3-((3-N-benzoyloxy-3-N-(2-trans-dodecenoyl))propyl)diamide citrate

2-tert-butyl-1,3-((3-N-benzoyloxy-3-N-crotonyl)propyl)diamide citrate

2-tert-butyl-1,3-((3-N-benzoyloxy-3-N-acetyl)propyl)diamide citrate