2-chloro-4-{[3-(2,6-dimethylphenyl)-5-isopropylisoxazol-4-yl]methoxy}benzoic acid

Base Information

Chemical Name:2-chloro-4-{[3-(2,6-dimethylphenyl)-5-isopropylisoxazol-4-yl]methoxy}benzoic acid
CAS No.:1374961-82-6
Molecular Formula:C₂₂H₂₂ClNO₄
Molecular Weight:399.874
Hs Code.:

Synonyms:2-chloro-4-{[3-(2,6-dimethylphenyl)-5-isopropylisoxazol-4-yl]methoxy}benzoic acid

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Chemical Property of 2-chloro-4-{[3-(2,6-dimethylphenyl)-5-isopropylisoxazol-4-yl]methoxy}benzoic acid

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Technology Process of 2-chloro-4-{[3-(2,6-dimethylphenyl)-5-isopropylisoxazol-4-yl]methoxy}benzoic acid

There total 5 articles about 2-chloro-4-{[3-(2,6-dimethylphenyl)-5-isopropylisoxazol-4-yl]methoxy}benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1374961-79-1
2-chloro-4-{[3-(2,6-dimethylphenyl)-5-isopropylisoxazol-4-yl]methoxy}benzaldehyde

: 1374961-82-6
2-chloro-4-{[3-(2,6-dimethylphenyl)-5-isopropylisoxazol-4-yl]methoxy}benzoic acid

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; tert-butyl alcohol; at 20 ℃;
DOI:10.1016/j.bmc.2012.03.016

Reference yield:

: 86793-93-3
N-hydroxy-2,6-dimethylbenzene-1-carbonimidoyl chloride

: 1374961-82-6
2-chloro-4-{[3-(2,6-dimethylphenyl)-5-isopropylisoxazol-4-yl]methoxy}benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: sodium methylate; triethylamine / methanol / 20 °C

2: diisobutylaluminium hydride / tetrahydrofuran / 0 °C

3: carbon tetrabromide; triphenylphosphine / dichloromethane / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

5: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / water; tert-butyl alcohol / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; carbon tetrabromide; sodium methylate; diisobutylaluminium hydride; potassium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.bmc.2012.03.016

Reference yield:

: 1374961-73-5
methyl 3-(2,6-dimethylphenyl)-5-isopropylisoxazole-4-carboxylate

: 1374961-82-6
2-chloro-4-{[3-(2,6-dimethylphenyl)-5-isopropylisoxazol-4-yl]methoxy}benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: diisobutylaluminium hydride / tetrahydrofuran / 0 °C

2: carbon tetrabromide; triphenylphosphine / dichloromethane / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

4: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / water; tert-butyl alcohol / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; carbon tetrabromide; diisobutylaluminium hydride; potassium carbonate; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.bmc.2012.03.016