2-chloro-4-{[3-(2,6-dimethylphenyl)-5-isopropylisoxazol-4-yl]methoxy}benzaldehyde

Base Information

Chemical Name:2-chloro-4-{[3-(2,6-dimethylphenyl)-5-isopropylisoxazol-4-yl]methoxy}benzaldehyde
CAS No.:1374961-79-1
Molecular Formula:C₂₂H₂₂ClNO₃
Molecular Weight:383.875
Hs Code.:

Synonyms:2-chloro-4-{[3-(2,6-dimethylphenyl)-5-isopropylisoxazol-4-yl]methoxy}benzaldehyde

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Chemical Property of 2-chloro-4-{[3-(2,6-dimethylphenyl)-5-isopropylisoxazol-4-yl]methoxy}benzaldehyde

Chemical Property:

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Technology Process of 2-chloro-4-{[3-(2,6-dimethylphenyl)-5-isopropylisoxazol-4-yl]methoxy}benzaldehyde

There total 6 articles about 2-chloro-4-{[3-(2,6-dimethylphenyl)-5-isopropylisoxazol-4-yl]methoxy}benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

: 1374961-76-8
C₁₅H₁₈BrNO

: 1374961-79-1
2-chloro-4-{[3-(2,6-dimethylphenyl)-5-isopropylisoxazol-4-yl]methoxy}benzaldehyde

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1016/j.bmc.2012.03.016

Reference yield:

: 86793-93-3
N-hydroxy-2,6-dimethylbenzene-1-carbonimidoyl chloride

: 1374961-79-1
2-chloro-4-{[3-(2,6-dimethylphenyl)-5-isopropylisoxazol-4-yl]methoxy}benzaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: sodium methylate; triethylamine / methanol / 20 °C

2: diisobutylaluminium hydride / tetrahydrofuran / 0 °C

3: carbon tetrabromide; triphenylphosphine / dichloromethane / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

With carbon tetrabromide; sodium methylate; diisobutylaluminium hydride; potassium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.03.016

Reference yield:

: 1374961-73-5
methyl 3-(2,6-dimethylphenyl)-5-isopropylisoxazole-4-carboxylate

: 1374961-79-1
2-chloro-4-{[3-(2,6-dimethylphenyl)-5-isopropylisoxazol-4-yl]methoxy}benzaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: diisobutylaluminium hydride / tetrahydrofuran / 0 °C

2: carbon tetrabromide; triphenylphosphine / dichloromethane / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

With carbon tetrabromide; diisobutylaluminium hydride; potassium carbonate; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.03.016