(-)-17-(cyclobutylmethyl)-N-methyl-N-(2-methoxybenzyl)-morphinan-3-amine

Base Information

Chemical Name:(-)-17-(cyclobutylmethyl)-N-methyl-N-(2-methoxybenzyl)-morphinan-3-amine
CAS No.:1372134-24-1
Molecular Formula:C₃₀H₄₀N₂O
Molecular Weight:444.66
Hs Code.:

Synonyms:(-)-17-(cyclobutylmethyl)-N-methyl-N-(2-methoxybenzyl)-morphinan-3-amine

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Chemical Property of (-)-17-(cyclobutylmethyl)-N-methyl-N-(2-methoxybenzyl)-morphinan-3-amine

Chemical Property:

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Technology Process of (-)-17-(cyclobutylmethyl)-N-methyl-N-(2-methoxybenzyl)-morphinan-3-amine

There total 6 articles about (-)-17-(cyclobutylmethyl)-N-methyl-N-(2-methoxybenzyl)-morphinan-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1372133-90-8
(-)-17-(cyclobutylmethyl)-N-(2-methoxybenzyl)morphinan-3-amine

: 1372134-24-1
(-)-17-(cyclobutylmethyl)-N-methyl-N-(2-methoxybenzyl)-morphinan-3-amine

Guidance literature:: With sodium tetrahydroborate; trifluoroacetic acid; In tetrahydrofuran; at 20 ℃; for 72h;
DOI:10.1021/jm3001086

Reference yield:

: 4163-26-2
butorphan

: 1372134-24-1
(-)-17-(cyclobutylmethyl)-N-methyl-N-(2-methoxybenzyl)-morphinan-3-amine

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dichloromethane / 20 °C

2: tol-BINAP; palladium diacetate; caesium carbonate / tetrahydrofuran / 24 h / Reflux

3: hydroxylamine hydrochloride; sodium acetate / methanol / 24 h / 20 °C

4: sodium sulfate / methanol / 20 °C / Inert atmosphere

5: sodium tetrahydroborate / methanol / 4 h / 20 °C / Inert atmosphere

6: sodium tetrahydroborate; trifluoroacetic acid / tetrahydrofuran / 72 h / 20 °C

With tol-BINAP; sodium tetrahydroborate; hydroxylamine hydrochloride; sodium acetate; palladium diacetate; caesium carbonate; sodium sulfate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; 2: Buchwald-Hartwig reaction;
DOI:10.1021/jm3001086

Reference yield:

: C₂₉H₃₆N₂O

: 1372134-24-1
(-)-17-(cyclobutylmethyl)-N-methyl-N-(2-methoxybenzyl)-morphinan-3-amine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 4 h / 20 °C / Inert atmosphere

2: sodium tetrahydroborate; trifluoroacetic acid / tetrahydrofuran / 72 h / 20 °C

With sodium tetrahydroborate; trifluoroacetic acid; In tetrahydrofuran; methanol;
DOI:10.1021/jm3001086