rac-2-(benzyloxycarbonyl-amino)-3-[(8-trifluoromethanesulfonyloxy-quinoline-2-carbonyl)amino]propionic acid methyl ester

Base Information

• Chemical Name: rac-2-(benzyloxycarbonyl-amino)-3-[(8-trifluoromethanesulfonyloxy-quinoline-2-carbonyl)amino]propionic acid methyl ester
• CAS No.: 1185410-62-1
• Molecular Formula: C₂₃H₂₀F₃N₃O₈S
• Molecular Weight: 555.488
• Mol file: 1185410-62-1.mol

Synonyms:rac-2-(benzyloxycarbonyl-amino)-3-[(8-trifluoromethanesulfonyloxy-quinoline-2-carbonyl)amino]propionic acid methyl ester

Chemical Property of rac-2-(benzyloxycarbonyl-amino)-3-[(8-trifluoromethanesulfonyloxy-quinoline-2-carbonyl)amino]propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of rac-2-(benzyloxycarbonyl-amino)-3-[(8-trifluoromethanesulfonyloxy-quinoline-2-carbonyl)amino]propionic acid methyl ester

There total 1 articles about rac-2-(benzyloxycarbonyl-amino)-3-[(8-trifluoromethanesulfonyloxy-quinoline-2-carbonyl)amino]propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-hydroxy-quinoline-2-carboxylic acid (1571-30-8) + trifluoromethylsulfonic anhydride (358-23-6) + methyl ester of N-alpha-(CO2-CH2-phenyl)-alpha,beta-diaminopropionic acid (185564-12-9) → rac-2-(benzyloxycarbonyl-amino)-3-[(8-trifluoromethanesulfonyloxy-quinoline-2-carbonyl)amino]propionic acid methyl ester (1185410-62-1)

Guidance literature:

8-hydroxy-quinoline-2-carboxylic acid; trifluoromethylsulfonic anhydride; With triethylamine; In dichloromethane; at -70 ℃;

methyl ester of N-alpha-(CO₂-CH₂-phenyl)-alpha,beta-diaminopropionic acid; In 1,4-dioxane; dichloromethane; at 0 - 20 ℃;

With sodium hydrogencarbonate; In 1,4-dioxane; dichloromethane; water; ethyl acetate;

Reference yield:

rac-2-(benzyloxycarbonyl-amino)-3-[(8-trifluoromethanesulfonyloxy-quinoline-2-carbonyl)amino]propionic acid methyl ester (1185410-62-1) + 1-Naphthylboronic acid (13922-41-3) → rac-2-(benzyloxycarbonyl-amino)-3-[(8-naphthalen-1-yl-quinoline-2-carbonyl)amino]propionic acid methyl ester (1185410-64-3)

Guidance literature:

With potassium phosphate; palladium diacetate; XPhos; In tert-butyl alcohol; at 80 ℃; for 1.16667h; Inert atmosphere;

upstream raw materials:

8-hydroxy-quinoline-2-carboxylic acid

trifluoromethylsulfonic anhydride

methyl ester of N-alpha-(CO₂-CH₂-phenyl)-alpha,beta-diaminopropionic acid

Downstream raw materials:

rac-2-(benzyloxycarbonyl-amino)-3-[(8-naphthalen-1-yl-quinoline-2-carbonyl)amino]propionic acid methyl ester