rac-2-(benzyloxycarbonyl-amino)-3-[(8-naphthalen-1-yl-quinoline-2-carbonyl)amino]propionic acid methyl ester

Base Information

Chemical Name:rac-2-(benzyloxycarbonyl-amino)-3-[(8-naphthalen-1-yl-quinoline-2-carbonyl)amino]propionic acid methyl ester
CAS No.:1185410-64-3
Molecular Formula:C₃₂H₂₇N₃O₅
Molecular Weight:533.583
Hs Code.:

Synonyms:rac-2-(benzyloxycarbonyl-amino)-3-[(8-naphthalen-1-yl-quinoline-2-carbonyl)amino]propionic acid methyl ester

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Chemical Property of rac-2-(benzyloxycarbonyl-amino)-3-[(8-naphthalen-1-yl-quinoline-2-carbonyl)amino]propionic acid methyl ester

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Technology Process of rac-2-(benzyloxycarbonyl-amino)-3-[(8-naphthalen-1-yl-quinoline-2-carbonyl)amino]propionic acid methyl ester

There total 2 articles about rac-2-(benzyloxycarbonyl-amino)-3-[(8-naphthalen-1-yl-quinoline-2-carbonyl)amino]propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1185410-62-1
rac-2-(benzyloxycarbonyl-amino)-3-[(8-trifluoromethanesulfonyloxy-quinoline-2-carbonyl)amino]propionic acid methyl ester

: 13922-41-3
1-Naphthylboronic acid

: 1185410-64-3
rac-2-(benzyloxycarbonyl-amino)-3-[(8-naphthalen-1-yl-quinoline-2-carbonyl)amino]propionic acid methyl ester

Guidance literature:: With potassium phosphate; palladium diacetate; XPhos; In tert-butyl alcohol; at 80 ℃; for 1.16667h; Inert atmosphere;

Reference yield:

: 1571-30-8
8-hydroxy-quinoline-2-carboxylic acid

: 185564-12-9
methyl ester of N-alpha-(CO₂-CH₂-phenyl)-alpha,beta-diaminopropionic acid

: 1185410-64-3
rac-2-(benzyloxycarbonyl-amino)-3-[(8-naphthalen-1-yl-quinoline-2-carbonyl)amino]propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / -70 °C

1.2: 0 - 20 °C

2.1: potassium phosphate / palladium diacetate; XPhos / tert-butyl alcohol / 1.17 h / 80 °C / Inert atmosphere

With potassium phosphate; triethylamine; palladium diacetate; XPhos; In dichloromethane; tert-butyl alcohol;