(E)-ethyl 2-hydroxy-2-phenyl-3-(pyrrolidin-1-ylimino)propanoate

Base Information

• Chemical Name: (E)-ethyl 2-hydroxy-2-phenyl-3-(pyrrolidin-1-ylimino)propanoate
• CAS No.: 1330591-17-7
• Molecular Formula: C₁₅H₂₀N₂O₃
• Molecular Weight: 276.335
• Mol file: 1330591-17-7.mol

Synonyms:(E)-ethyl 2-hydroxy-2-phenyl-3-(pyrrolidin-1-ylimino)propanoate

Chemical Property of (E)-ethyl 2-hydroxy-2-phenyl-3-(pyrrolidin-1-ylimino)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (E)-ethyl 2-hydroxy-2-phenyl-3-(pyrrolidin-1-ylimino)propanoate

There total 1 articles about (E)-ethyl 2-hydroxy-2-phenyl-3-(pyrrolidin-1-ylimino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

phenylglyoxylic acid ethyl ester (1603-79-8) + formaldehyde N,N-tetramethylenehydrazone (60144-26-5) → (E)-ethyl 2-hydroxy-2-phenyl-3-(pyrrolidin-1-ylimino)propanoate (1330591-17-7)

Guidance literature:

phenylglyoxylic acid ethyl ester; With 1,3-bis(3,5-bis(trifluoro-ethyl)phenyl)thiourea; In water; at 20 ℃; for 0.25h;

formaldehyde N,N-tetramethylenehydrazone; In water;

DOI:10.1002/asia.201100174

Reference yield: 57.0%

(E)-ethyl 2-hydroxy-2-phenyl-3-(pyrrolidin-1-ylimino)propanoate (1330591-17-7) → ethyl α-cyano-α-hydroxyphenylacetate (147506-75-0,131221-75-5)

Guidance literature:

With monoperoxyphthalic acid magnesium salt hexahydrate; In dichloromethane; at 20 ℃; for 6h;

DOI:10.1002/asia.201100174

upstream raw materials:

phenylglyoxylic acid ethyl ester

formaldehyde N,N-tetramethylenehydrazone

Downstream raw materials:

ethyl α-cyano-α-hydroxyphenylacetate