2-(4-(1H-pyrazol-3-yl-amino)-2-(4-fluorophenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-N,N-dimethylacetamide

Base Information

Chemical Name:2-(4-(1H-pyrazol-3-yl-amino)-2-(4-fluorophenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-N,N-dimethylacetamide
CAS No.:1361960-49-7
Molecular Formula:C₁₉H₁₈FN₇O₃S
Molecular Weight:443.461
Hs Code.:

Synonyms:2-(4-(1H-pyrazol-3-yl-amino)-2-(4-fluorophenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-N,N-dimethylacetamide

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Chemical Property of 2-(4-(1H-pyrazol-3-yl-amino)-2-(4-fluorophenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-N,N-dimethylacetamide

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Technology Process of 2-(4-(1H-pyrazol-3-yl-amino)-2-(4-fluorophenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-N,N-dimethylacetamide

There total 5 articles about 2-(4-(1H-pyrazol-3-yl-amino)-2-(4-fluorophenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-N,N-dimethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 1820-80-0,916420-28-5
3-aminopyrazole

: 1361961-07-0
2-(4-chloro-2-(4-fluorophenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-N,N-dimethylacetamide

: 1361960-49-7
2-(4-(1H-pyrazol-3-yl-amino)-2-(4-fluorophenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-N,N-dimethylacetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; sodium iodide; In N,N-dimethyl-formamide; at 80 ℃; for 46h;

Reference yield:

: 1361960-94-2
4-chloro-2-(4-fluorophenylthio)-7H-pyrrolo[2,3-d]pyrimidine

: 1361960-49-7
2-(4-(1H-pyrazol-3-yl-amino)-2-(4-fluorophenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-N,N-dimethylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

1.2: 1 h / 0 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane; N,N-dimethyl-formamide / 21.17 h / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine; sodium iodide / N,N-dimethyl-formamide / 46 h / 80 °C

With sodium hydride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; sodium iodide; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1361960-93-1
2-(4-fluorophenylthio)-7H-pyrrolo[2,3-d]pyrimidin-4-ol

: 1361960-49-7
2-(4-(1H-pyrazol-3-yl-amino)-2-(4-fluorophenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-N,N-dimethylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / 1 h / 110 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

2.2: 1 h / 0 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane; N,N-dimethyl-formamide / 21.17 h / 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine; sodium iodide / N,N-dimethyl-formamide / 46 h / 80 °C

With sodium hydride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; sodium iodide; trichlorophosphate; In dichloromethane; N,N-dimethyl-formamide; mineral oil;