(R)-1-Benzyl-2-((S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-1,2,3,4-tetrahydro-isoquinoline

Base Information

• Chemical Name: (R)-1-Benzyl-2-((S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-1,2,3,4-tetrahydro-isoquinoline
• CAS No.: 102922-33-8
• Molecular Formula: C₂₂H₂₆N₂O
• Molecular Weight: 334.461

Synonyms:(R)-1-Benzyl-2-((S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-1,2,3,4-tetrahydro-isoquinoline

Chemical Property of (R)-1-Benzyl-2-((S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-1,2,3,4-tetrahydro-isoquinoline

Chemical Property:

Purity/Quality:

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Technology Process of (R)-1-Benzyl-2-((S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-1,2,3,4-tetrahydro-isoquinoline

There total 2 articles about (R)-1-Benzyl-2-((S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-1,2,3,4-tetrahydro-isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl bromide (100-39-0) + 2-((S)-4-Isopropyl-4,5-dihydro-oxazol-2-yl)-1,2,3,4-tetrahydro-isoquinoline (102922-30-5) → (R)-1-Benzyl-2-((S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-1,2,3,4-tetrahydro-isoquinoline (102922-33-8) + (S)-1-Benzyl-2-((S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-1,2,3,4-tetrahydro-isoquinoline (119109-84-1)

Guidance literature:

With tert.-butyl lithium; In tetrahydrofuran; Product distribution; Mechanism; multistep reaction; 1.) -78 deg C, 2.) -100 deg C; various temperature;

DOI:10.1021/ja00188a040

Reference yield:

benzyl chloride (100-44-7) + 2-((S)-4-Isopropyl-4,5-dihydro-oxazol-2-yl)-1,2,3,4-tetrahydro-isoquinoline (102922-30-5) → (R)-1-Benzyl-2-((S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-1,2,3,4-tetrahydro-isoquinoline (102922-33-8) + (S)-1-Benzyl-2-((S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-1,2,3,4-tetrahydro-isoquinoline (119109-84-1)

Guidance literature:

With tert.-butyl lithium; In tetrahydrofuran; Product distribution; Mechanism; multistep reaction; 1.) -78 deg C, 2.) -90 deg C; various temperature;

DOI:10.1021/ja00188a040

Reference yield:

(R)-1-Benzyl-2-((S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-1,2,3,4-tetrahydro-isoquinoline (102922-33-8) → (S)-valinol (2026-48-4,473-75-6) + (1S)-1-benzyl-1,2,3,4-tetrahydroisoquinoline (57680-86-1) + (1R)-1-benzyl-1,2,3,4-tetrahydroisoquinoline (57680-87-2)

Guidance literature:

With toluene-4-sulfonic acid; hydrazine hydrate; In ethanol; for 6h; Heating;

DOI:10.1021/ja00188a040

upstream raw materials:

benzyl bromide

2-((S)-4-Isopropyl-4,5-dihydro-oxazol-2-yl)-1,2,3,4-tetrahydro-isoquinoline

benzyl chloride

Downstream raw materials:

(S)-valinol

(1S)-1-benzyl-1,2,3,4-tetrahydroisoquinoline

(1R)-1-benzyl-1,2,3,4-tetrahydroisoquinoline

(4S)-4-isopropyl-1,3-oxazolidin-2-one

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