4-(5-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)benzene sulfonamide

Base Information

Chemical Name:4-(5-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)benzene sulfonamide
CAS No.:1346457-93-9
Molecular Formula:C₂₃H₂₂FN₃O₄S
Molecular Weight:455.51
Hs Code.:

Synonyms:4-(5-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)benzene sulfonamide

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Chemical Property of 4-(5-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)benzene sulfonamide

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Technology Process of 4-(5-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)benzene sulfonamide

There total 4 articles about 4-(5-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)benzene sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 17852-52-7,27918-19-0
4-hydrazinobenzene-1-sulfonamide hydrochloride

: 28081-14-3
(E)-1-(4-fluorophenyl)-3-(3,4-dimethoxyphenyl)prop-2-en-1-one

: 1346457-93-9
4-(5-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)benzene sulfonamide

Guidance literature:: With acetic acid; In ethanol; for 12h; Reflux;
DOI:10.1007/s00044-011-9823-x

Reference yield: 32.0%

: 28081-14-3
1-(4-fluorophenyl)-3-(3,4-dimethoxyphenyl)prop-2-en-1-one

: 17852-52-7,27918-19-0
4-hydrazinobenzene-1-sulfonamide hydrochloride

: 1346457-93-9
4-(5-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)benzene sulfonamide

Guidance literature:: With acetic acid; In ethanol; for 4h; Reflux;
DOI:10.1016/j.bioorg.2018.12.028

Reference yield:

: 403-42-9
1-(4-fluorophenyl)ethanone

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 1346457-93-9
4-(5-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)benzene sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / methanol / 18 h / 20 °C

2: acetic acid / ethanol / 12 h / Reflux

With acetic acid; sodium hydroxide; In methanol; ethanol;
DOI:10.1007/s00044-011-9823-x