Bromazine hydrochloride

Base Information

• Chemical Name: Bromazine hydrochloride
• CAS No.: 1808-12-4
• Molecular Formula: C17H20 Br N O . Cl H
• Molecular Weight: 370.717
• Hs Code.: 2922190900
• European Community (EC) Number: 217-310-9
• NSC Number: 36113
• UNII: 202J683U97
• DSSTox Substance ID: DTXSID70904541
• Wikidata: Q27126511
• NCI Thesaurus Code: C47421
• Pharos Ligand ID: ABLNZVJHDR3H
• ChEMBL ID: CHEMBL1200967
• Mol file: 1808-12-4.mol

Synonyms:ambodryl;bromazine;bromodiphenhydramine;bromodiphenhydramine hydrochloride

Chemical Property of Bromazine hydrochloride

Chemical Property:

• Vapor Pressure: 1.61E-06mmHg at 25°C
• Melting Point: 144-145°
• Boiling Point: 397.3°C at 760 mmHg
• Flash Point: 194.1°C
• PSA: 12.47000
• LogP: 4.91870
• Storage Temp.: Refrigerator
• Solubility.: Acetone (Slightly), Methanol (Slightly), Water (Slightly)
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 369.04950
• Heavy Atom Count: 21
• Complexity: 258

Purity/Quality:

99%, ^*data from raw suppliers

BromazineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CCOC(C1=CC=CC=C1)C2=CC=C(C=C2)Br.Cl
• Description: Bromodiphenhydramine is a histamine H1 receptor antagonist. It induces histamine release in isolated guinea pig lung when used at a concentration of 1 mM but completely prevents ovalbumin-induced histamine release in lungs isolated from ovalbumin-sensitized guinea pigs when used at concentrations of 100 and 200 μg/ml. Bromodiphenhydramine (17 mg/kg) inhibits formalin-induced paw edema in rats. It increases survival in a mouse model of systemic S. typhimurium infection when administered at doses of 1.5 and 3 mg/kg.
• Uses: Antihistaminic.

Technology Process of Bromazine hydrochloride

There total 3 articles about Bromazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[(4-bromophenyl)phenylmethoxy]-N,N-dimethylethaneamine (118-23-0,29048-32-6) → [2-(4-bromo-benzhydryloxy)-ethyl]-dimethyl-amine; hydrochloride (1808-12-4)

Guidance literature:

With hydrogenchloride; In diethyl ether; water;

DOI:10.1007/s00044-011-9891-y

Reference yield:

phenyl(4-bromophenyl)methanol (29334-16-5) → [2-(4-bromo-benzhydryloxy)-ethyl]-dimethyl-amine; hydrochloride (1808-12-4)

Guidance literature:

Multi-step reaction with 3 steps

1: Acetyl bromide / benzene / 11 h / Reflux

2: 5,5-dimethyl-1,3-cyclohexadiene / 24 h / Reflux

3: hydrogenchloride / diethyl ether; water

With hydrogenchloride; Acetyl bromide; In 5,5-dimethyl-1,3-cyclohexadiene; diethyl ether; water; benzene;

DOI:10.1007/s00044-011-9891-y

Reference yield:

1-bromo-4-<(bromophenyl)methyl>benzene (18066-89-2) → [2-(4-bromo-benzhydryloxy)-ethyl]-dimethyl-amine; hydrochloride (1808-12-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 5,5-dimethyl-1,3-cyclohexadiene / 24 h / Reflux

2: hydrogenchloride / diethyl ether; water

With hydrogenchloride; In 5,5-dimethyl-1,3-cyclohexadiene; diethyl ether; water;

DOI:10.1007/s00044-011-9891-y

upstream raw materials:

2-[(4-bromophenyl)phenylmethoxy]-N,N-dimethylethaneamine

phenyl(4-bromophenyl)methanol

1-bromo-4-<(bromophenyl)methyl>benzene

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