Bromazine

Base Information

Chemical Name:Bromazine
CAS No.:118-23-0
Molecular Formula:C₁₇H₂₀BrNO
Molecular Weight:334.256
Hs Code.:2922199090
European Community (EC) Number:204-238-8
UNII:T032BI7727
DSSTox Substance ID:DTXSID6022688
Nikkaji Number:J5.295G
Wikipedia:Bromazine
Wikidata:Q4926102
NCI Thesaurus Code:C61654
Pharos Ligand ID:ABLNZVJHDR3H
Metabolomics Workbench ID:145958
ChEMBL ID:CHEMBL1201245
Mol file:118-23-0.mol

Synonyms:ambodryl;bromazine;bromodiphenhydramine;bromodiphenhydramine hydrochloride

Suppliers and Price of Bromazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
BROMODIPHENHYDRAMINE 95.00%
5MG
$ 505.58

American Custom Chemicals Corporation
DIPHENHYDRAMINE EP IMPURITY C 95.00%
5MG
$ 459.90

Total 18 raw suppliers

Chemical Property of Bromazine

Chemical Property:

Boiling Point:397.3°Cat760mmHg
PKA:pKa 8.64(H2O t = 25 c = 0.002 to 0.01) (Uncertain)
Flash Point:194.1°C
PSA：12.47000
Density:1.259g/cm³
LogP:4.11670
XLogP3:4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:333.07283
Heavy Atom Count:20
Complexity:258

Purity/Quality:

98%,99%, ^*data from raw suppliers

BROMODIPHENHYDRAMINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C)CCOC(C1=CC=CC=C1)C2=CC=C(C=C2)Br
Uses Antihistaminic.
Therapeutic Function Antihistaminic

Technology Process of Bromazine

There total 3 articles about Bromazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 108-01-0
2-(N,N-dimethylamino)ethanol

: 18066-89-2
1-bromo-4-<(bromophenyl)methyl>benzene

: 118-23-0,29048-32-6
2-[(4-bromophenyl)phenylmethoxy]-N,N-dimethylethaneamine

Guidance literature:: In para-xylene; for 24h; Reflux; Inert atmosphere;
DOI:10.1021/acs.joc.9b03032

Reference yield:

: 29334-16-5
phenyl(4-bromophenyl)methanol

: 118-23-0,29048-32-6
2-[(4-bromophenyl)phenylmethoxy]-N,N-dimethylethaneamine

Guidance literature:: Multi-step reaction with 2 steps

1: Acetyl bromide / benzene / 11 h / Reflux

2: 5,5-dimethyl-1,3-cyclohexadiene / 24 h / Reflux

With Acetyl bromide; In 5,5-dimethyl-1,3-cyclohexadiene; benzene;
DOI:10.1007/s00044-011-9891-y