1-(4-(1-(2-(4-amino-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-1H-1,2,3-triazol-4-yl)phenyl)ethanone

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Chemical Name:1-(4-(1-(2-(4-amino-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-1H-1,2,3-triazol-4-yl)phenyl)ethanone
CAS No.:1286278-55-4
Molecular Formula:C₂₃H₂₀N₈O
Molecular Weight:424.465
Hs Code.:

Synonyms:1-(4-(1-(2-(4-amino-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-1H-1,2,3-triazol-4-yl)phenyl)ethanone

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Chemical Property of 1-(4-(1-(2-(4-amino-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-1H-1,2,3-triazol-4-yl)phenyl)ethanone

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Technology Process of 1-(4-(1-(2-(4-amino-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-1H-1,2,3-triazol-4-yl)phenyl)ethanone

There total 7 articles about 1-(4-(1-(2-(4-amino-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-1H-1,2,3-triazol-4-yl)phenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1286278-44-1
1-(2-azidoethyl)-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

: 42472-69-5
4-ethynylacetophenone

: 1286278-55-4
1-(4-(1-(2-(4-amino-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-1H-1,2,3-triazol-4-yl)phenyl)ethanone

Guidance literature:: With copper(II) sulfate; sodium L-ascorbate; In dimethyl sulfoxide; acetonitrile; at 20 ℃; for 3h; regioselective reaction;
DOI:10.1016/j.bmcl.2011.01.047

Reference yield:

: 1286278-42-9
C₁₃H₁₃N₅O

: 1286278-55-4
1-(4-(1-(2-(4-amino-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-1H-1,2,3-triazol-4-yl)phenyl)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 2 h / 20 °C

2: sodium azide / N,N-dimethyl-formamide / 3 h / 20 °C

3: copper(II) sulfate; sodium L-ascorbate / dimethyl sulfoxide; acetonitrile / 3 h / 20 °C

With pyridine; sodium azide; copper(II) sulfate; sodium L-ascorbate; In dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2011.01.047

Reference yield:

: 1286278-43-0
C₁₄H₁₅N₅O₃S

: 1286278-55-4
1-(4-(1-(2-(4-amino-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-1H-1,2,3-triazol-4-yl)phenyl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide / N,N-dimethyl-formamide / 3 h / 20 °C

2: copper(II) sulfate; sodium L-ascorbate / dimethyl sulfoxide; acetonitrile / 3 h / 20 °C

With sodium azide; copper(II) sulfate; sodium L-ascorbate; In dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2011.01.047