1286278-43-0Relevant articles and documents
Development of the phenylpyrazolo[3,4-d]pyrimidine-based, insulin-like growth factor receptor/Src/AXLtargeting small molecule kinase inhibitor
Lee, Ho Jin,Pham, Phuong Chi,Pei, Honglan,Lim, Bumhee,Hyun, Seung Yeob,Baek, Byungyeob,Kim, Byungjin,Kim, Yunha,Kim, Min-Hwan,Kang, Nae-Won,Min, Hye-Young,Kim, Dae-Duk,Lee, Jeeyeon,Lee, Ho-Young
, p. 1918 - 1936 (2021/01/06)
Rationale: The type I insulin-like growth factor receptor (IGF-1R) signaling pathway plays key roles in the development and progression of numerous types of human cancers, and Src and AXL have been found to confer resistance to anti-IGF-1R therapies. Henc
Synthesis of 3-phenylpyrazolopyrimidine-1,2,3-triazole conjugates and evaluation of their Src kinase inhibitory and anticancer activities
Kumar, Anil,Ahmad, Israr,Chhikara, Bhupender S.,Tiwari, Rakesh,Mandal, Deendayal,Parang, Keykavous
, p. 1342 - 1346 (2011/04/16)
A series of two classes of 3-phenylpyrazolopyrimidine-1,2,3-triazole conjugates were synthesized using click chemistry approach. All compounds were evaluated for inhibition of Src kinase and human ovarian adenocarcinoma (SK-Ov-3), breast carcinoma (MDA-MB