N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-1-(2-hydroxyethyl)cyclopropanesulfonamide

Base Information

Chemical Name:N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-1-(2-hydroxyethyl)cyclopropanesulfonamide
CAS No.:1295575-01-7
Molecular Formula:C₂₅H₂₆F₂IN₃O₆S₂
Molecular Weight:693.531
Hs Code.:

Synonyms:N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-1-(2-hydroxyethyl)cyclopropanesulfonamide

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Chemical Property of N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-1-(2-hydroxyethyl)cyclopropanesulfonamide

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Technology Process of N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-1-(2-hydroxyethyl)cyclopropanesulfonamide

There total 12 articles about N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-1-(2-hydroxyethyl)cyclopropanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1295575-06-2
N-(3-{5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]-2-(6-hydroxy-4,4-dioxido-4-thia-5-azaspiro[2.4]hept-5-yl)phenoxy}phenyl)ethanesulfonamide

: 1295575-01-7
N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-1-(2-hydroxyethyl)cyclopropanesulfonamide

Guidance literature:: With methanol; sodium tetrahydroborate; at 0 ℃; for 1h;

Reference yield:

: 29632-74-4
2-fluro-4-iodoaniline

: 1295575-01-7
N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-1-(2-hydroxyethyl)cyclopropanesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 121 h / -10 - 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: sodium dithionite / water; tetrahydrofuran / 1 h / 50 °C

4.1: pyridine / 18 h / 0 - 20 °C

5.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

5.2: pH 10

6.1: pyridine / 18 h / 20 °C

7.1: 2,6-dimethylpyridine; sodium periodate; water / osmium(VIII) oxide / 1,4-dioxane / 18 h / 20 °C

8.1: sodium tetrahydroborate; methanol / 1 h / 0 °C

With pyridine; 2,6-dimethylpyridine; methanol; sodium tetrahydroborate; sodium periodate; sodium dithionite; water; caesium carbonate; trifluoroacetic acid; lithium hexamethyldisilazane; osmium(VIII) oxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 315-14-0
1,3,5-trifluoro-2-nitrobenzene

: 1295575-01-7
N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-1-(2-hydroxyethyl)cyclopropanesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 121 h / -10 - 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: sodium dithionite / water; tetrahydrofuran / 1 h / 50 °C

4.1: pyridine / 18 h / 0 - 20 °C

5.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

5.2: pH 10

6.1: pyridine / 18 h / 20 °C

7.1: 2,6-dimethylpyridine; sodium periodate; water / osmium(VIII) oxide / 1,4-dioxane / 18 h / 20 °C

8.1: sodium tetrahydroborate; methanol / 1 h / 0 °C

With pyridine; 2,6-dimethylpyridine; methanol; sodium tetrahydroborate; sodium periodate; sodium dithionite; water; caesium carbonate; trifluoroacetic acid; lithium hexamethyldisilazane; osmium(VIII) oxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;