2-(Ethoxyoxalyl-amino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid benzyl ester

Base Information

Chemical Name:2-(Ethoxyoxalyl-amino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid benzyl ester
CAS No.:188411-48-5
Molecular Formula:C₂₀H₂₁NO₅S
Molecular Weight:387.456
Hs Code.:

Synonyms:2-(Ethoxyoxalyl-amino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid benzyl ester

Suppliers and Price of 2-(Ethoxyoxalyl-amino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 2-(Ethoxyoxalyl-amino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid benzyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(Ethoxyoxalyl-amino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid benzyl ester

There total 3 articles about 2-(Ethoxyoxalyl-amino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 4755-77-5
Ethyl oxalyl chloride

: 188411-47-4
benzyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

: 188411-48-5
2-(Ethoxyoxalyl-amino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid benzyl ester

Guidance literature:: With triethylamine; In dichloromethane; 0 deg C, 0.5 h; room temperature, 20 h;
DOI:10.1080/00397919708006049

Reference yield:

: 4506-71-2
ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

: 188411-48-5
2-(Ethoxyoxalyl-amino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / aq. NaOH / methanol / Heating

2: 76 percent / K₂CO₃ / dimethylformamide / 20 h / Ambient temperature

3: 100 percent / Et₃N / CH₂Cl₂ / 0 deg C, 0.5 h; room temperature, 20 h

With sodium hydroxide; potassium carbonate; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1080/00397919708006049

Reference yield:

: 5936-58-3
2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid

: 188411-48-5
2-(Ethoxyoxalyl-amino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / K₂CO₃ / dimethylformamide / 20 h / Ambient temperature

2: 100 percent / Et₃N / CH₂Cl₂ / 0 deg C, 0.5 h; room temperature, 20 h

With potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1080/00397919708006049