[4-(3-ethyl-4-phenylethynylphenylethynyl)-3-fluorophenylethynyl]trimethylsilane

Base Information

Chemical Name:[4-(3-ethyl-4-phenylethynylphenylethynyl)-3-fluorophenylethynyl]trimethylsilane
CAS No.:518342-96-6
Molecular Formula:C₂₉H₂₅FSi
Molecular Weight:420.601
Hs Code.:

Synonyms:[4-(3-ethyl-4-phenylethynylphenylethynyl)-3-fluorophenylethynyl]trimethylsilane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [4-(3-ethyl-4-phenylethynylphenylethynyl)-3-fluorophenylethynyl]trimethylsilane

Chemical Property:

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Technology Process of [4-(3-ethyl-4-phenylethynylphenylethynyl)-3-fluorophenylethynyl]trimethylsilane

There total 11 articles about [4-(3-ethyl-4-phenylethynylphenylethynyl)-3-fluorophenylethynyl]trimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 518342-64-8
(3-fluoro-4-iodophenylethynyl)trimethylsilane

: 518342-74-0
2-ethyl-4-ethynyl-1-(phenylethynyl)benzene

: 518342-96-6
[4-(3-ethyl-4-phenylethynylphenylethynyl)-3-fluorophenylethynyl]trimethylsilane

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1016/S0040-4020(02)01409-6

Reference yield:

: 536-74-3
phenylacetylene

: 518342-96-6
[4-(3-ethyl-4-phenylethynylphenylethynyl)-3-fluorophenylethynyl]trimethylsilane

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / PdCl₂(PPh₃)2; CuI; PPh₃ / i-Pr₂NEt / tetrahydrofuran / 72 h / 20 °C

2: 94 percent / K₂CO₃ / methanol

3: 70 percent / PdCl₂(PPh₃)2; CuI; i-Pr₂NEt / tetrahydrofuran / 24 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; 1: Sonogashira coupling / 3: Sonogashira coupling;
DOI:10.1016/S0040-4020(02)01409-6

Reference yield:

: 29632-74-4
2-fluro-4-iodoaniline

: 518342-96-6
[4-(3-ethyl-4-phenylethynylphenylethynyl)-3-fluorophenylethynyl]trimethylsilane

Guidance literature:: Multi-step reaction with 3 steps

1.1: Pd(PPh₃)2Cl₂; CuI; triethylamine / 20 °C

2.1: BF₃*Et₂O; t-BuONO / diethyl ether / -20 - 5 °C

2.2: 8.97 g / NaI; I₂ / acetonitrile / 1 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tert.-butylnitrite; boron trifluoride diethyl etherate; triethylamine; In diethyl ether; 1.1: Sonogashira coupling;
DOI:10.1016/S0040-4020(02)01409-6