(S)-(-)-(Z)-4-[4-acetyl-1-(4-bromobenzenesulfonyl)-2,5-dihydro-1H-pyrrol-3-yl]-2-methyl-3-phenylpent-3-enoic acid ethyl ester

Base Information

Chemical Name:(S)-(-)-(Z)-4-[4-acetyl-1-(4-bromobenzenesulfonyl)-2,5-dihydro-1H-pyrrol-3-yl]-2-methyl-3-phenylpent-3-enoic acid ethyl ester
CAS No.:1309881-44-4
Molecular Formula:C₂₆H₂₈BrNO₅S
Molecular Weight:546.482
Hs Code.:

Synonyms:(S)-(-)-(Z)-4-[4-acetyl-1-(4-bromobenzenesulfonyl)-2,5-dihydro-1H-pyrrol-3-yl]-2-methyl-3-phenylpent-3-enoic acid ethyl ester

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Chemical Property of (S)-(-)-(Z)-4-[4-acetyl-1-(4-bromobenzenesulfonyl)-2,5-dihydro-1H-pyrrol-3-yl]-2-methyl-3-phenylpent-3-enoic acid ethyl ester

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Technology Process of (S)-(-)-(Z)-4-[4-acetyl-1-(4-bromobenzenesulfonyl)-2,5-dihydro-1H-pyrrol-3-yl]-2-methyl-3-phenylpent-3-enoic acid ethyl ester

There total 1 articles about (S)-(-)-(Z)-4-[4-acetyl-1-(4-bromobenzenesulfonyl)-2,5-dihydro-1H-pyrrol-3-yl]-2-methyl-3-phenylpent-3-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 887266-64-0
N,N-bis(2-butynyl)-(4-bromophenyl)sulfonamide

: 10488-87-6
ethyl 2-benzoylpropionate

: (E)-4-[4-acetyl-1-(4-bromobenzenesulfonyl)-2,5-dihydro-1H-pyrrol-3-yl]-2-methyl-3-phenylpent-3-enoic acid ethyl ester

: 1309881-44-4
(S)-(-)-(Z)-4-[4-acetyl-1-(4-bromobenzenesulfonyl)-2,5-dihydro-1H-pyrrol-3-yl]-2-methyl-3-phenylpent-3-enoic acid ethyl ester

Guidance literature:: With bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R)-(+)-2,2'-bis(diphenylphosphanyl)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl; In dichloromethane; at 20 ℃; for 1h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1002/anie.201007727

Reference yield: 99.0%

: 1309881-44-4
(S)-(-)-(Z)-4-[4-acetyl-1-(4-bromobenzenesulfonyl)-2,5-dihydro-1H-pyrrol-3-yl]-2-methyl-3-phenylpent-3-enoic acid ethyl ester

: 1309881-88-6
C₂₄H₂₈BrNO₄S

Guidance literature:: With diisobutylaluminium hydride; In hexane; benzene; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1002/anie.201007727

Reference yield:

: 1309881-44-4
(S)-(-)-(Z)-4-[4-acetyl-1-(4-bromobenzenesulfonyl)-2,5-dihydro-1H-pyrrol-3-yl]-2-methyl-3-phenylpent-3-enoic acid ethyl ester

: 1309881-89-7
C₃₆H₅₆BrNO₄SSi₂

Guidance literature:: Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / hexane; benzene / 2 h / 20 °C / Inert atmosphere

2: 1H-imidazole / N,N-dimethyl-formamide / 40 h / 20 °C / Inert atmosphere

With 1H-imidazole; diisobutylaluminium hydride; In hexane; N,N-dimethyl-formamide; benzene;
DOI:10.1002/anie.201007727