2-METHYL-3-OXO-3-PHENYL-PROPIONIC ACID ETHYL ESTER

Base Information

• Chemical Name: 2-METHYL-3-OXO-3-PHENYL-PROPIONIC ACID ETHYL ESTER
• CAS No.: 10488-87-6
• Molecular Formula: C12H14 O3
• Molecular Weight: 206.241
• Mol file: 10488-87-6.mol

Synonyms:Propionicacid, 2-benzoyl-, ethyl ester (6CI,7CI,8CI); Ethyl 2-benzoylpropanoate; Ethyl2-benzoylpropionate; Ethyl 2-methyl-3-oxo-3-phenylpropanoate; Ethyl2-methyl-3-oxo-3-phenylpropionate; Ethyl a-benzoylpropionate; Ethyl a-methylbenzoylacetate; NSC 102730; NSC 67276; a-Methyl-b-oxobenzenepropanoic acid ethylester

Chemical Property of 2-METHYL-3-OXO-3-PHENYL-PROPIONIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 0.00407mmHg at 25°C
• Refractive Index: 1.5070 to 1.5110
• Boiling Point: 279.2°Cat760mmHg
• PKA: 10.93±0.26(Predicted)
• Flash Point: 117.9°C
• PSA: 43.37000
• Density: 1.08g/cm³
• LogP: 2.06850
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

Ethyl2-Methyl-3-oxo-3-phenylpropanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-METHYL-3-OXO-3-PHENYL-PROPIONIC ACID ETHYL ESTER

There total 69 articles about 2-METHYL-3-OXO-3-PHENYL-PROPIONIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl 3-oxo-3-phenylpropionate (94-02-0) + methyl iodide (74-88-4) → ethyl 2-benzoylpropionate (10488-87-6)

Guidance literature:

ethyl 3-oxo-3-phenylpropionate; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; Inert atmosphere;

methyl iodide; In tetrahydrofuran; mineral oil; at 20 ℃; for 20h; Inert atmosphere;

DOI:10.1002/chem.201001539

Reference yield: 94.0%

ethyl 3-oxo-3-phenylpropionate (94-02-0) → ethyl 2-benzoylpropionate (10488-87-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; Inert atmosphere;

DOI:10.1002/anie.201403587

Reference yield: 93.0%

diazoacetic acid ethyl ester (623-73-4) + benzoyltrimethylsilane (5908-41-8) + methyl iodide (74-88-4) → ethyl 2-benzoylpropionate (10488-87-6)

Guidance literature:

diazoacetic acid ethyl ester; benzoyltrimethylsilane; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran; at -78 - 0 ℃; Further stages.;

DOI:10.1039/b801597j

upstream raw materials:

piperidine

diethyl ether

ethyl 2-bromo-2-methyl-3-oxo-3-phenylpropanoate

monoethyl methylmalonate

Downstream raw materials:

4-methyl-2-(1-methyl-piperidin-4-yl)-5-phenyl-1,2-dihydro-pyrazol-3-one

2-dimethylaminomethyl-2-methyl-3-oxo-3-phenyl-propionic acid ethyl ester

4-methyl-2,5-diphenyl-1,2-dihydro-pyrazol-3-one

ethyl 2-methyl-2-allyl-3-oxo-3-phenylpropanoate