Technology Process of (Z)-(3S,6S,7S,8S)-3,9-Bis-(tert-butyl-diphenyl-silanyloxy)-7-methoxymethoxy-6,8-dimethyl-non-4-enal
There total 12 articles about (Z)-(3S,6S,7S,8S)-3,9-Bis-(tert-butyl-diphenyl-silanyloxy)-7-methoxymethoxy-6,8-dimethyl-non-4-enal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone;
In
water; acetone;
DOI:10.1021/ol034958l
- Guidance literature:
-
Multi-step reaction with 12 steps
1: 91 percent / diethyl ether / -78 °C
2: 89 percent / (i-Pr)2NEt / CH2Cl2 / -78 °C
3: 85 percent / Grubbs' catalyst / CH2Cl2 / Heating
4: Dibal-H / CH2Cl2 / -78 °C
5: NaBH4 / methanol / 0 °C
6: pyridine / 25 °C
7: (i-Pr)2NEt / CH2Cl2 / 25 °C
8: 93 percent / Dibal-H / CH2Cl2 / -78 °C
9: 90 percent / (COCl)2; DMSO; Et3N / CH2Cl2 / -78 °C
10: diethyl ether / -78 °C
11: 93 percent / imidazole / CH2Cl2
12: 89 percent / OsO4; NMO; NaIO4 / acetone; H2O
With
pyridine; 1H-imidazole; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; oxalyl dichloride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine;
Grubbs catalyst first generation;
In
methanol; diethyl ether; dichloromethane; water; acetone;
9: Swern oxidation;
DOI:10.1021/ol034958l
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 89 percent / (i-Pr)2NEt / CH2Cl2 / -78 °C
2: 85 percent / Grubbs' catalyst / CH2Cl2 / Heating
3: Dibal-H / CH2Cl2 / -78 °C
4: NaBH4 / methanol / 0 °C
5: pyridine / 25 °C
6: (i-Pr)2NEt / CH2Cl2 / 25 °C
7: 93 percent / Dibal-H / CH2Cl2 / -78 °C
8: 90 percent / (COCl)2; DMSO; Et3N / CH2Cl2 / -78 °C
9: diethyl ether / -78 °C
10: 93 percent / imidazole / CH2Cl2
11: 89 percent / OsO4; NMO; NaIO4 / acetone; H2O
With
pyridine; 1H-imidazole; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; oxalyl dichloride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine;
Grubbs catalyst first generation;
In
methanol; diethyl ether; dichloromethane; water; acetone;
8: Swern oxidation;
DOI:10.1021/ol034958l
