1,7-Dodecadien-4-ol, 6,12-bis[[(1,1-dimethylethyl)diphenylsilyl]oxy]-10-(methoxymethoxy)-3,9, 11-trimethyl-, (3R,4S,6S,7Z,9S,10S,11S)-

Base Information

Chemical Name:1,7-Dodecadien-4-ol, 6,12-bis[[(1,1-dimethylethyl)diphenylsilyl]oxy]-10-(methoxymethoxy)-3,9, 11-trimethyl-, (3R,4S,6S,7Z,9S,10S,11S)-
CAS No.:600714-93-0
Molecular Formula:C49H68O5Si2
Molecular Weight:793.247
Hs Code.:

Synonyms:

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Chemical Property of 1,7-Dodecadien-4-ol, 6,12-bis[[(1,1-dimethylethyl)diphenylsilyl]oxy]-10-(methoxymethoxy)-3,9, 11-trimethyl-, (3R,4S,6S,7Z,9S,10S,11S)-

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Technology Process of 1,7-Dodecadien-4-ol, 6,12-bis[[(1,1-dimethylethyl)diphenylsilyl]oxy]-10-(methoxymethoxy)-3,9, 11-trimethyl-, (3R,4S,6S,7Z,9S,10S,11S)-

There total 13 articles about 1,7-Dodecadien-4-ol, 6,12-bis[[(1,1-dimethylethyl)diphenylsilyl]oxy]-10-(methoxymethoxy)-3,9, 11-trimethyl-, (3R,4S,6S,7Z,9S,10S,11S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 92817-88-4
(2S)-3-{[tert-butyl(diphenyl)silyl]oxy}-2-methylpropanal

: 600714-93-0
(Z)-(3R,4S,6S,9S,10S,11S)-6,12-Bis-(tert-butyl-diphenyl-silanyloxy)-10-methoxymethoxy-3,9,11-trimethyl-dodeca-1,7-dien-4-ol

Guidance literature:: Multi-step reaction with 13 steps

1: 91 percent / diethyl ether / -78 °C

2: 89 percent / (i-Pr)2NEt / CH₂Cl₂ / -78 °C

3: 85 percent / Grubbs' catalyst / CH₂Cl₂ / Heating

4: Dibal-H / CH₂Cl₂ / -78 °C

5: NaBH₄ / methanol / 0 °C

6: pyridine / 25 °C

7: (i-Pr)2NEt / CH₂Cl₂ / 25 °C

8: 93 percent / Dibal-H / CH₂Cl₂ / -78 °C

9: 90 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 °C

10: diethyl ether / -78 °C

11: 93 percent / imidazole / CH₂Cl₂

12: 89 percent / OsO₄; NMO; NaIO₄ / acetone; H₂O

13: diethyl ether / -78 °C

With pyridine; 1H-imidazole; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; oxalyl dichloride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; Grubbs catalyst first generation; In methanol; diethyl ether; dichloromethane; water; acetone; 9: Swern oxidation;
DOI:10.1021/ol034958l

Reference yield:

: 106357-24-8
(3S,4S,5S)-6-(tert-butyldiphenylsiloxy)-4-hydroxy-3,5-dimethylhexan-1-ene

: 600714-93-0
(Z)-(3R,4S,6S,9S,10S,11S)-6,12-Bis-(tert-butyl-diphenyl-silanyloxy)-10-methoxymethoxy-3,9,11-trimethyl-dodeca-1,7-dien-4-ol

Guidance literature:: Multi-step reaction with 12 steps

1: 89 percent / (i-Pr)2NEt / CH₂Cl₂ / -78 °C

2: 85 percent / Grubbs' catalyst / CH₂Cl₂ / Heating

3: Dibal-H / CH₂Cl₂ / -78 °C

4: NaBH₄ / methanol / 0 °C

5: pyridine / 25 °C

6: (i-Pr)2NEt / CH₂Cl₂ / 25 °C

7: 93 percent / Dibal-H / CH₂Cl₂ / -78 °C

8: 90 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 °C

9: diethyl ether / -78 °C

10: 93 percent / imidazole / CH₂Cl₂

11: 89 percent / OsO₄; NMO; NaIO₄ / acetone; H₂O

12: diethyl ether / -78 °C

With pyridine; 1H-imidazole; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; oxalyl dichloride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; Grubbs catalyst first generation; In methanol; diethyl ether; dichloromethane; water; acetone; 8: Swern oxidation;
DOI:10.1021/ol034958l

Reference yield:

: 468738-71-8
(1S,2S)-1-{(1S)-2-[(tert-butyldiphenylsilyl)oxy]-1-methylethyl}-2-methylbut-3-enyl prop-2-enoate

: 600714-93-0
(Z)-(3R,4S,6S,9S,10S,11S)-6,12-Bis-(tert-butyl-diphenyl-silanyloxy)-10-methoxymethoxy-3,9,11-trimethyl-dodeca-1,7-dien-4-ol

Guidance literature:: Multi-step reaction with 11 steps

1: 85 percent / Grubbs' catalyst / CH₂Cl₂ / Heating

2: Dibal-H / CH₂Cl₂ / -78 °C

3: NaBH₄ / methanol / 0 °C

4: pyridine / 25 °C

5: (i-Pr)2NEt / CH₂Cl₂ / 25 °C

6: 93 percent / Dibal-H / CH₂Cl₂ / -78 °C

7: 90 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 °C

8: diethyl ether / -78 °C

9: 93 percent / imidazole / CH₂Cl₂

10: 89 percent / OsO₄; NMO; NaIO₄ / acetone; H₂O

11: diethyl ether / -78 °C

With pyridine; 1H-imidazole; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; oxalyl dichloride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; Grubbs catalyst first generation; In methanol; diethyl ether; dichloromethane; water; acetone; 7: Swern oxidation;
DOI:10.1021/ol034958l