2-(p-chlorophenylaminosulfonylmethyl)-5-(4-p-chlorophenyl-1H-pyrrol-3-ylsulfonylmethyl)-1,3,4-thiadiazole

Base Information

Chemical Name:2-(p-chlorophenylaminosulfonylmethyl)-5-(4-p-chlorophenyl-1H-pyrrol-3-ylsulfonylmethyl)-1,3,4-thiadiazole
CAS No.:1370346-46-5
Molecular Formula:C₂₀H₁₆Cl₂N₄O₄S₃
Molecular Weight:543.475
Hs Code.:

Synonyms:2-(p-chlorophenylaminosulfonylmethyl)-5-(4-p-chlorophenyl-1H-pyrrol-3-ylsulfonylmethyl)-1,3,4-thiadiazole

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Chemical Property of 2-(p-chlorophenylaminosulfonylmethyl)-5-(4-p-chlorophenyl-1H-pyrrol-3-ylsulfonylmethyl)-1,3,4-thiadiazole

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Technology Process of 2-(p-chlorophenylaminosulfonylmethyl)-5-(4-p-chlorophenyl-1H-pyrrol-3-ylsulfonylmethyl)-1,3,4-thiadiazole

There total 5 articles about 2-(p-chlorophenylaminosulfonylmethyl)-5-(4-p-chlorophenyl-1H-pyrrol-3-ylsulfonylmethyl)-1,3,4-thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1370346-37-4
2-(p-chlorophenylaminosulfonylmethyl)-5-[Z-(p-chlorostyrylsulfonylmethyl)]-1,3,4-thiadiazole

: 38622-91-2,36635-61-7
[(p-methylphenyl)sulfonylmethyl]isonitrile

: 1370346-46-5
2-(p-chlorophenylaminosulfonylmethyl)-5-(4-p-chlorophenyl-1H-pyrrol-3-ylsulfonylmethyl)-1,3,4-thiadiazole

Guidance literature:: With sodium hydride; In diethyl ether; dimethyl sulfoxide; at 20 ℃;
DOI:10.1248/cpb.59.1509

Reference yield:

: 1136056-29-5
methyl 2-(N-(4-chlorophenyl)sulfamoyl)acetate

: 1370346-46-5
2-(p-chlorophenylaminosulfonylmethyl)-5-(4-p-chlorophenyl-1H-pyrrol-3-ylsulfonylmethyl)-1,3,4-thiadiazole

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine; hydrazine hydrate / methanol / Reflux

2: trichlorophosphate / Reflux

3: thiourea / tetrahydrofuran / 120 - 130 °C

4: sodium hydride / diethyl ether; dimethyl sulfoxide / 20 °C

With pyridine; sodium hydride; hydrazine hydrate; thiourea; trichlorophosphate; In tetrahydrofuran; methanol; diethyl ether; dimethyl sulfoxide;
DOI:10.1248/cpb.59.1509

Reference yield:

: [(Z)-2-(4-Chloro-phenyl)-ethenesulfonyl]-acetic acid

: 1370346-46-5
2-(p-chlorophenylaminosulfonylmethyl)-5-(4-p-chlorophenyl-1H-pyrrol-3-ylsulfonylmethyl)-1,3,4-thiadiazole

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / Reflux

2: thiourea / tetrahydrofuran / 120 - 130 °C

3: sodium hydride / diethyl ether; dimethyl sulfoxide / 20 °C

With sodium hydride; thiourea; trichlorophosphate; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide;
DOI:10.1248/cpb.59.1509