2-(p-chlorophenylaminosulfonylmethyl)-5-[Z-(p-chlorostyrylsulfonylmethyl)]-1,3,4-oxadiazole

Base Information

• Chemical Name: 2-(p-chlorophenylaminosulfonylmethyl)-5-[Z-(p-chlorostyrylsulfonylmethyl)]-1,3,4-oxadiazole
• CAS No.: 1370346-34-1
• Molecular Formula: C₁₈H₁₅Cl₂N₃O₅S₂
• Molecular Weight: 488.372

Synonyms:2-(p-chlorophenylaminosulfonylmethyl)-5-[Z-(p-chlorostyrylsulfonylmethyl)]-1,3,4-oxadiazole

Chemical Property of 2-(p-chlorophenylaminosulfonylmethyl)-5-[Z-(p-chlorostyrylsulfonylmethyl)]-1,3,4-oxadiazole

Chemical Property:

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Technology Process of 2-(p-chlorophenylaminosulfonylmethyl)-5-[Z-(p-chlorostyrylsulfonylmethyl)]-1,3,4-oxadiazole

There total 2 articles about 2-(p-chlorophenylaminosulfonylmethyl)-5-[Z-(p-chlorostyrylsulfonylmethyl)]-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

[(Z)-2-(4-Chloro-phenyl)-ethenesulfonyl]-acetic acid + (N-4-chlorophenylsulfamoyl)acetic acid hydrazide (67542-00-1) → 2-(p-chlorophenylaminosulfonylmethyl)-5-[Z-(p-chlorostyrylsulfonylmethyl)]-1,3,4-oxadiazole (1370346-34-1)

Guidance literature:

With trichlorophosphate; Reflux;

DOI:10.1248/cpb.59.1509

Reference yield:

methyl 2-(N-(4-chlorophenyl)sulfamoyl)acetate (1136056-29-5) → 2-(p-chlorophenylaminosulfonylmethyl)-5-[Z-(p-chlorostyrylsulfonylmethyl)]-1,3,4-oxadiazole (1370346-34-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; hydrazine hydrate / methanol / Reflux

2: trichlorophosphate / Reflux

With pyridine; hydrazine hydrate; trichlorophosphate; In methanol;

DOI:10.1248/cpb.59.1509

Reference yield: 74.0%

2-(p-chlorophenylaminosulfonylmethyl)-5-[Z-(p-chlorostyrylsulfonylmethyl)]-1,3,4-oxadiazole (1370346-34-1) + benzaldehyde phenylhydrazone (588-64-7) → 2-((p-chlorophenylaminosulfonyl)methyl)-5-((4',5'-dihydro-1',3'-diphenyl-5'-(p-chlorophenyl)-1'H-pyrazol-4'-ylsulfonyl)methyl)-1,3,4-oxadiazole (1595281-69-8)

Guidance literature:

With chloroamine-T; In methanol; Reflux;

DOI:10.1248/cpb.c13-00652

upstream raw materials:

(N-4-chlorophenylsulfamoyl)acetic acid hydrazide

methyl 2-(N-(4-chlorophenyl)sulfamoyl)acetate

Downstream raw materials:

2-(p-chlorophenylaminosulfonylmethyl)-5-(4-p-chlorophenyl-4,5-dihydro-1H-pyrazol-3-ylsulfonylmethyl)-1,3,4-oxadiazole

2-(p-chlorophenylaminosulfonylmethyl)-5-[Z-(p-chlorostyrylsulfonylmethyl)]-1,3,4-thiadiazole

4-amino-3-(p-chlorophenylaminosulfonylmethyl)-5-[Z-(p-chlorostyrylsulfonylmethyl)]-1,2,4-triazole

2-(p-chlorophenylaminosulfonylmethyl)-5-(4-p-chlorophenyl-1H-pyrrol-3-ylsulfonylmethyl)-1,3,4-thiadiazole

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