methyl (2Z,4E,6R,7S,8S,10E,12E,14S)-14-((4R,5S,6R)-6-((2S,3S)-3-(tert-butyldiphenylsilyloxy)butan-2-yl)-2,2,5-trimethyl-1,3-dioxan-4-yl)-2,14-dimethoxy-4,6,8,10-tetramethyl-7-(triethylsilyloxy)tetradeca-2,4,10,12-tetraenoate

Base Information

• Chemical Name: methyl (2Z,4E,6R,7S,8S,10E,12E,14S)-14-((4R,5S,6R)-6-((2S,3S)-3-(tert-butyldiphenylsilyloxy)butan-2-yl)-2,2,5-trimethyl-1,3-dioxan-4-yl)-2,14-dimethoxy-4,6,8,10-tetramethyl-7-(triethylsilyloxy)tetradeca-2,4,10,12-tetraenoate
• CAS No.: 1132969-97-1
• Molecular Formula: C₅₄H₈₆O₈Si₂
• Molecular Weight: 919.443
• Mol file: 1132969-97-1.mol

Synonyms:methyl (2Z,4E,6R,7S,8S,10E,12E,14S)-14-((4R,5S,6R)-6-((2S,3S)-3-(tert-butyldiphenylsilyloxy)butan-2-yl)-2,2,5-trimethyl-1,3-dioxan-4-yl)-2,14-dimethoxy-4,6,8,10-tetramethyl-7-(triethylsilyloxy)tetradeca-2,4,10,12-tetraenoate

Chemical Property of methyl (2Z,4E,6R,7S,8S,10E,12E,14S)-14-((4R,5S,6R)-6-((2S,3S)-3-(tert-butyldiphenylsilyloxy)butan-2-yl)-2,2,5-trimethyl-1,3-dioxan-4-yl)-2,14-dimethoxy-4,6,8,10-tetramethyl-7-(triethylsilyloxy)tetradeca-2,4,10,12-tetraenoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (2Z,4E,6R,7S,8S,10E,12E,14S)-14-((4R,5S,6R)-6-((2S,3S)-3-(tert-butyldiphenylsilyloxy)butan-2-yl)-2,2,5-trimethyl-1,3-dioxan-4-yl)-2,14-dimethoxy-4,6,8,10-tetramethyl-7-(triethylsilyloxy)tetradeca-2,4,10,12-tetraenoate

There total 1 articles about methyl (2Z,4E,6R,7S,8S,10E,12E,14S)-14-((4R,5S,6R)-6-((2S,3S)-3-(tert-butyldiphenylsilyloxy)butan-2-yl)-2,2,5-trimethyl-1,3-dioxan-4-yl)-2,14-dimethoxy-4,6,8,10-tetramethyl-7-(triethylsilyloxy)tetradeca-2,4,10,12-tetraenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

C53H84O8Si2 (1132970-11-6) + methyl iodide (74-88-4) → methyl (2Z,4E,6R,7S,8S,10E,12E,14S)-14-((4R,5S,6R)-6-((2S,3S)-3-(tert-butyldiphenylsilyloxy)butan-2-yl)-2,2,5-trimethyl-1,3-dioxan-4-yl)-2,14-dimethoxy-4,6,8,10-tetramethyl-7-(triethylsilyloxy)tetradeca-2,4,10,12-tetraenoate (1132969-97-1)

Guidance literature:

With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 20 ℃; for 1.41667h; Inert atmosphere;

DOI:10.1002/anie.200804645

Reference yield: 91.0%

methyl (2Z,4E,6R,7S,8S,10E,12E,14S)-14-((4R,5S,6R)-6-((2S,3S)-3-(tert-butyldiphenylsilyloxy)butan-2-yl)-2,2,5-trimethyl-1,3-dioxan-4-yl)-2,14-dimethoxy-4,6,8,10-tetramethyl-7-(triethylsilyloxy)tetradeca-2,4,10,12-tetraenoate (1132969-97-1) → (2Z,4E,6R,7S,8S,10E,12E,14S)-methyl 14-((4R,5S,6R)-6-((2S,3S)-3-(tert-butyldiphenylsilyloxy)butan-2-yl)-2,2,5-trimethyl-1,3-dioxan-4-yl)-7-hydroxy-2,14-dimethoxy-4,6,8,10-tetramethyltetradeca-2,4,10,12-tetraenoate (1132970-12-7)

Guidance literature:

With pyridine hydrogenfluoride; In tetrahydrofuran; at 0 - 20 ℃; for 7.16667h; Inert atmosphere;

DOI:10.1002/anie.200804645

upstream raw materials:

C₅₃H₈₄O₈Si₂

methyl iodide

Downstream raw materials:

(2Z,4E,6R,7S,8S,10E,12E,14S)-methyl 14-((4R,5S,6R)-6-((2S,3S)-3-(tert-butyldiphenylsilyloxy)butan-2-yl)-2,2,5-trimethyl-1,3-dioxan-4-yl)-7-hydroxy-2,14-dimethoxy-4,6,8,10-tetramethyltetradeca-2,4,10,12-tetraenoate