3-[3-(5-iodopyrimidin-2-yl)benzyl]-5-trifluoromethyl-3H-benzothiazol-2-one

Base Information

Chemical Name:3-[3-(5-iodopyrimidin-2-yl)benzyl]-5-trifluoromethyl-3H-benzothiazol-2-one
CAS No.:1234056-21-3
Molecular Formula:C₁₉H₁₁F₃IN₃OS
Molecular Weight:513.282
Hs Code.:

Synonyms:3-[3-(5-iodopyrimidin-2-yl)benzyl]-5-trifluoromethyl-3H-benzothiazol-2-one

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Chemical Property of 3-[3-(5-iodopyrimidin-2-yl)benzyl]-5-trifluoromethyl-3H-benzothiazol-2-one

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Technology Process of 3-[3-(5-iodopyrimidin-2-yl)benzyl]-5-trifluoromethyl-3H-benzothiazol-2-one

There total 4 articles about 3-[3-(5-iodopyrimidin-2-yl)benzyl]-5-trifluoromethyl-3H-benzothiazol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1234055-91-4
3-[3-(5-bromopyrimidin-2-yl)benzyl]-5-trifluoromethyl-3H-benzothiazol-2-one

: 1234056-21-3
3-[3-(5-iodopyrimidin-2-yl)benzyl]-5-trifluoromethyl-3H-benzothiazol-2-one

Guidance literature:: With trans-N,N-dimethyl-cyclohexane-1,2-diamine; sodium iodide; copper(l) iodide; In 1,4-dioxane; for 120h; Inert atmosphere; Reflux;

Reference yield:

: 87199-15-3
[3-(hydroxymethyl)phenyl]boronic acid

: 1234056-21-3
3-[3-(5-iodopyrimidin-2-yl)benzyl]-5-trifluoromethyl-3H-benzothiazol-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: potassium phosphate tribasic trihydrate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / 90 °C / Inert atmosphere

2: thionyl chloride / dichloromethane / 3 h / 20 °C / Cooling

3: caesium carbonate / N,N-dimethyl-formamide / 18 h / 20 - 80 °C

4: sodium iodide; trans-N,N-dimethyl-cyclohexane-1,2-diamine / copper(l) iodide / 1,4-dioxane / 120 h / Inert atmosphere; Reflux

With thionyl chloride; trans-N,N-dimethyl-cyclohexane-1,2-diamine; potassium phosphate tribasic trihydrate; caesium carbonate; sodium iodide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1100598-50-2
5-bromo-2-(3-chloromethyl-phenyl)-pyrimidine

: 1234056-21-3
3-[3-(5-iodopyrimidin-2-yl)benzyl]-5-trifluoromethyl-3H-benzothiazol-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 20 - 80 °C

2: sodium iodide; trans-N,N-dimethyl-cyclohexane-1,2-diamine / copper(l) iodide / 1,4-dioxane / 120 h / Inert atmosphere; Reflux

With trans-N,N-dimethyl-cyclohexane-1,2-diamine; caesium carbonate; sodium iodide; copper(l) iodide; In 1,4-dioxane; N,N-dimethyl-formamide;