3-{3-[5-(4-methylpiperazin-1-yl)pyrimidin-2-yl]benzyl}-5-trifluoromethyl-3H-benzothiazol-2-one trifluoroacetate

Base Information

Chemical Name:3-{3-[5-(4-methylpiperazin-1-yl)pyrimidin-2-yl]benzyl}-5-trifluoromethyl-3H-benzothiazol-2-one trifluoroacetate
CAS No.:1234056-41-7
Molecular Formula:C₂HF₃O₂*C₂₄H₂₂F₃N₅OS
Molecular Weight:599.557
Hs Code.:

Synonyms:3-{3-[5-(4-methylpiperazin-1-yl)pyrimidin-2-yl]benzyl}-5-trifluoromethyl-3H-benzothiazol-2-one trifluoroacetate

Suppliers and Price of 3-{3-[5-(4-methylpiperazin-1-yl)pyrimidin-2-yl]benzyl}-5-trifluoromethyl-3H-benzothiazol-2-one trifluoroacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-{3-[5-(4-methylpiperazin-1-yl)pyrimidin-2-yl]benzyl}-5-trifluoromethyl-3H-benzothiazol-2-one trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-{3-[5-(4-methylpiperazin-1-yl)pyrimidin-2-yl]benzyl}-5-trifluoromethyl-3H-benzothiazol-2-one trifluoroacetate

There total 5 articles about 3-{3-[5-(4-methylpiperazin-1-yl)pyrimidin-2-yl]benzyl}-5-trifluoromethyl-3H-benzothiazol-2-one trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1234056-21-3
3-[3-(5-iodopyrimidin-2-yl)benzyl]-5-trifluoromethyl-3H-benzothiazol-2-one

: 76-05-1
trifluoroacetic acid

: 1234056-41-7
3-{3-[5-(4-methylpiperazin-1-yl)pyrimidin-2-yl]benzyl}-5-trifluoromethyl-3H-benzothiazol-2-one trifluoroacetate

Guidance literature:: 1-methyl-piperazine; 3-[3-(5-iodopyrimidin-2-yl)benzyl]-5-trifluoromethyl-3H-benzothiazol-2-one; With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate tribasic trihydrate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In toluene; at 100 ℃; Inert atmosphere;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 1100598-50-2
5-bromo-2-(3-chloromethyl-phenyl)-pyrimidine

: 1234056-41-7
3-{3-[5-(4-methylpiperazin-1-yl)pyrimidin-2-yl]benzyl}-5-trifluoromethyl-3H-benzothiazol-2-one trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 20 - 80 °C

2: sodium iodide; trans-N,N-dimethyl-cyclohexane-1,2-diamine / copper(l) iodide / 1,4-dioxane / 120 h / Inert atmosphere; Reflux

3: potassium phosphate tribasic trihydrate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 100 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; trans-N,N-dimethyl-cyclohexane-1,2-diamine; potassium phosphate tribasic trihydrate; caesium carbonate; sodium iodide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; In 1,4-dioxane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1092568-90-5
(3-(5-bromopyrimidin-2-yl)phenyl)methanol

: 1234056-41-7
3-{3-[5-(4-methylpiperazin-1-yl)pyrimidin-2-yl]benzyl}-5-trifluoromethyl-3H-benzothiazol-2-one trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / dichloromethane / 3 h / 20 °C / Cooling

2: caesium carbonate / N,N-dimethyl-formamide / 18 h / 20 - 80 °C

3: sodium iodide; trans-N,N-dimethyl-cyclohexane-1,2-diamine / copper(l) iodide / 1,4-dioxane / 120 h / Inert atmosphere; Reflux

4: potassium phosphate tribasic trihydrate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 100 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; thionyl chloride; trans-N,N-dimethyl-cyclohexane-1,2-diamine; potassium phosphate tribasic trihydrate; caesium carbonate; sodium iodide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene;