ethyl (2R,3S)-2-[(tert-butoxycarbonyl)amino]-4-(diethoxyphosphoryl)-3-phenylbutanoate

Base Information

Chemical Name:ethyl (2R,3S)-2-[(tert-butoxycarbonyl)amino]-4-(diethoxyphosphoryl)-3-phenylbutanoate
CAS No.:618893-45-1
Molecular Formula:C₂₁H₃₄NO₇P
Molecular Weight:443.477
Hs Code.:

Synonyms:ethyl (2R,3S)-2-[(tert-butoxycarbonyl)amino]-4-(diethoxyphosphoryl)-3-phenylbutanoate

Suppliers and Price of ethyl (2R,3S)-2-[(tert-butoxycarbonyl)amino]-4-(diethoxyphosphoryl)-3-phenylbutanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl (2R,3S)-2-[(tert-butoxycarbonyl)amino]-4-(diethoxyphosphoryl)-3-phenylbutanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl (2R,3S)-2-[(tert-butoxycarbonyl)amino]-4-(diethoxyphosphoryl)-3-phenylbutanoate

There total 7 articles about ethyl (2R,3S)-2-[(tert-butoxycarbonyl)amino]-4-(diethoxyphosphoryl)-3-phenylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 182207-43-8
ethyl (2R,3S)-2-amino-3-phenyl-4-(diethoxyphosphoryl)butanoate

: 618893-45-1
ethyl (2R,3S)-2-[(tert-butoxycarbonyl)amino]-4-(diethoxyphosphoryl)-3-phenylbutanoate

Guidance literature:: With sodium hydrogencarbonate; sodium carbonate; In 1,4-dioxane; water; for 3h; Ambient temperature;
DOI:10.1016/0040-4039(96)01230-0

Reference yield:

: 182207-34-7
(2R,5S,1'S)-3,6-diethoxy-2-[2'-(diethoxyphosphoryl)-1'-phenylethyl]-2,5-dihydro-5-isopropylpyrazine

: 618893-45-1
ethyl (2R,3S)-2-[(tert-butoxycarbonyl)amino]-4-(diethoxyphosphoryl)-3-phenylbutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / HCl / tetrahydrofuran / 15 h / 20 °C

2: 98 percent / Na₂CO₃; NaHCO₃ / dioxane; H₂O / 3 h / 0 - 20 °C

With hydrogenchloride; sodium hydrogencarbonate; sodium carbonate; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/jo034707q

Reference yield:

: 683-08-9
Diethyl methylphosphonate

: 618893-45-1
ethyl (2R,3S)-2-[(tert-butoxycarbonyl)amino]-4-(diethoxyphosphoryl)-3-phenylbutanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: LDA; (EtO)2P(O)Cl / tetrahydrofuran

1.2: tetrahydrofuran

2.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / -78 °C

2.2: tetrahydrofuran; hexane / 0 °C

3.1: 85 percent / HCl / tetrahydrofuran / 15 h / 20 °C

4.1: 98 percent / Na₂CO₃; NaHCO₃ / dioxane; H₂O / 3 h / 0 - 20 °C

With hydrogenchloride; n-butyllithium; sodium hydrogencarbonate; sodium carbonate; diethyl chlorophosphate; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; hexane; water; 1.2: Wadsworth-Emmons olefination;
DOI:10.1021/jo034707q