N-[(3S)-Tetrahydro-5-oxo-3-furanyl]benzamide

Base Information

Chemical Name:N-[(3S)-Tetrahydro-5-oxo-3-furanyl]benzamide
CAS No.:87219-30-5
Molecular Formula:C₁₁H₁₁NO₃
Molecular Weight:205.213
Hs Code.:
DSSTox Substance ID:DTXSID501256241

Synonyms:N-[(3S)-Tetrahydro-5-oxo-3-furanyl]benzamide;DTXSID501256241;87219-30-5

Suppliers and Price of N-[(3S)-Tetrahydro-5-oxo-3-furanyl]benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[(3S)-Tetrahydro-5-oxo-3-furanyl]benzamide

Chemical Property:

XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:205.07389321
Heavy Atom Count:15
Complexity:259

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1C(COC1=O)NC(=O)C2=CC=CC=C2
Isomeric SMILES:C1[C@@H](COC1=O)NC(=O)C2=CC=CC=C2

Technology Process of N-[(3S)-Tetrahydro-5-oxo-3-furanyl]benzamide

There total 3 articles about N-[(3S)-Tetrahydro-5-oxo-3-furanyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 102614-12-0
3(S)-amino-γ-butyrolactone hydrobromide

: 98-88-4
benzoyl chloride

: 87219-30-5
(S)-4-(N-benzoylamino)dihydrofuran-2(3H)-one

Guidance literature:: In pyridine; dichloromethane; at -2 ℃; for 48h;
DOI:10.1021/ja00276a040

Reference yield:

: (S)-3-Benzoylamino-4-hydroxy-butyric acid methyl ester

: 87219-30-5
(S)-4-(N-benzoylamino)dihydrofuran-2(3H)-one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 48h;
DOI:10.1016/j.tet.2007.03.026

Reference yield:

: 944410-98-4
methyl (S)-3-(benzoylamino)-4-benzoyloxybutanoate

: 87219-30-5
(S)-4-(N-benzoylamino)dihydrofuran-2(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: aq. LiOH / methanol / 18 h / 20 °C

2: 11.5 mg / TFA / CH₂Cl₂ / 48 h / 20 °C

With lithium hydroxide; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1016/j.tet.2007.03.026