N-[2(S)-(2(R)-t-butoxycarbonylamino-3-triphenylmethylmercaptopropylamino)-3(S)-methylpentyl]phenylalanyl-methionine

Base Information

Chemical Name:N-[2(S)-(2(R)-t-butoxycarbonylamino-3-triphenylmethylmercaptopropylamino)-3(S)-methylpentyl]phenylalanyl-methionine
CAS No.:150350-35-9
Molecular Formula:C₄₇H₆₂N₄O₅S₂
Molecular Weight:827.165
Hs Code.:

Synonyms:N-[2(S)-(2(R)-t-butoxycarbonylamino-3-triphenylmethylmercaptopropylamino)-3(S)-methylpentyl]phenylalanyl-methionine

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Chemical Property of N-[2(S)-(2(R)-t-butoxycarbonylamino-3-triphenylmethylmercaptopropylamino)-3(S)-methylpentyl]phenylalanyl-methionine

Chemical Property:

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Technology Process of N-[2(S)-(2(R)-t-butoxycarbonylamino-3-triphenylmethylmercaptopropylamino)-3(S)-methylpentyl]phenylalanyl-methionine

There total 7 articles about N-[2(S)-(2(R)-t-butoxycarbonylamino-3-triphenylmethylmercaptopropylamino)-3(S)-methylpentyl]phenylalanyl-methionine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 150350-34-8
N-[2(S)-(2(R)-t-butoxycarbonylamino-3-triphenylmethylmercaptopropylamino)-3(S)-methylpentyl]phenylalanyl-methionine methyl ester

: 150350-35-9
N-[2(S)-(2(R)-t-butoxycarbonylamino-3-triphenylmethylmercaptopropylamino)-3(S)-methylpentyl]phenylalanyl-methionine

Guidance literature:: With sodium hydroxide; In methanol; at 0 ℃;
DOI:10.1021/jm9800907

Reference yield:

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 150350-35-9
N-[2(S)-(2(R)-t-butoxycarbonylamino-3-triphenylmethylmercaptopropylamino)-3(S)-methylpentyl]phenylalanyl-methionine

Guidance literature:: Multi-step reaction with 6 steps

1: Na(OAc)3BH, Et₃N, 3A molecular sieves / 1,2-dichloro-ethane; dimethylformamide

2: 1 N aq. NaOH / methanol / Ambient temperature

3: HOBt, EDC, Et₃N / dimethylformamide / Ambient temperature

4: HCl (gas) / ethyl acetate / -25 °C

5: NaCNBH₃, KOAc, 3A molecular sieves / methanol / Ambient temperature

6: 1 N aq. NaOH / methanol / 0 °C

With hydrogenchloride; sodium hydroxide; 3 A molecular sieve; potassium acetate; sodium tris(acetoxy)borohydride; sodium cyanoborohydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In methanol; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm9800907

Reference yield:

: 118171-79-2,141321-51-9,141321-54-2,87694-55-1
N-(t-butoxycarbonyl)-isoleucine aldehyde

: 150350-35-9
N-[2(S)-(2(R)-t-butoxycarbonylamino-3-triphenylmethylmercaptopropylamino)-3(S)-methylpentyl]phenylalanyl-methionine

Guidance literature:: Multi-step reaction with 6 steps

1: Na(OAc)3BH, Et₃N, 3A molecular sieves / 1,2-dichloro-ethane; dimethylformamide

2: 1 N aq. NaOH / methanol / Ambient temperature

3: HOBt, EDC, Et₃N / dimethylformamide / Ambient temperature

4: HCl (gas) / ethyl acetate / -25 °C

5: NaCNBH₃, KOAc, 3A molecular sieves / methanol / Ambient temperature

6: 1 N aq. NaOH / methanol / 0 °C

With hydrogenchloride; sodium hydroxide; 3 A molecular sieve; potassium acetate; sodium tris(acetoxy)borohydride; sodium cyanoborohydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In methanol; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm9800907