N-[2(S)-(2(R)-t-butoxycarbonylamino-3-triphenylmethylmercaptopropylamino)-3(S)-methylpentyl]phenylalanyl-methionine methyl ester

Base Information

Chemical Name:N-[2(S)-(2(R)-t-butoxycarbonylamino-3-triphenylmethylmercaptopropylamino)-3(S)-methylpentyl]phenylalanyl-methionine methyl ester
CAS No.:150350-34-8
Molecular Formula:C₄₈H₆₄N₄O₅S₂
Molecular Weight:841.192
Hs Code.:

Synonyms:N-[2(S)-(2(R)-t-butoxycarbonylamino-3-triphenylmethylmercaptopropylamino)-3(S)-methylpentyl]phenylalanyl-methionine methyl ester

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Chemical Property of N-[2(S)-(2(R)-t-butoxycarbonylamino-3-triphenylmethylmercaptopropylamino)-3(S)-methylpentyl]phenylalanyl-methionine methyl ester

Chemical Property:

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Technology Process of N-[2(S)-(2(R)-t-butoxycarbonylamino-3-triphenylmethylmercaptopropylamino)-3(S)-methylpentyl]phenylalanyl-methionine methyl ester

There total 7 articles about N-[2(S)-(2(R)-t-butoxycarbonylamino-3-triphenylmethylmercaptopropylamino)-3(S)-methylpentyl]phenylalanyl-methionine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 150350-34-8
N-[2(S)-(2(R)-t-butoxycarbonylamino-3-triphenylmethylmercaptopropylamino)-3(S)-methylpentyl]phenylalanyl-methionine methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: Na(OAc)3BH, Et₃N, 3A molecular sieves / 1,2-dichloro-ethane; dimethylformamide

2: 1 N aq. NaOH / methanol / Ambient temperature

3: HOBt, EDC, Et₃N / dimethylformamide / Ambient temperature

4: HCl (gas) / ethyl acetate / -25 °C

5: NaCNBH₃, KOAc, 3A molecular sieves / methanol / Ambient temperature

With hydrogenchloride; sodium hydroxide; 3 A molecular sieve; potassium acetate; sodium tris(acetoxy)borohydride; sodium cyanoborohydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In methanol; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm9800907

Reference yield:

: 118171-79-2,141321-51-9,141321-54-2,87694-55-1
N-(t-butoxycarbonyl)-isoleucine aldehyde

: 150350-34-8
N-[2(S)-(2(R)-t-butoxycarbonylamino-3-triphenylmethylmercaptopropylamino)-3(S)-methylpentyl]phenylalanyl-methionine methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: Na(OAc)3BH, Et₃N, 3A molecular sieves / 1,2-dichloro-ethane; dimethylformamide

2: 1 N aq. NaOH / methanol / Ambient temperature

3: HOBt, EDC, Et₃N / dimethylformamide / Ambient temperature

4: HCl (gas) / ethyl acetate / -25 °C

5: NaCNBH₃, KOAc, 3A molecular sieves / methanol / Ambient temperature

With hydrogenchloride; sodium hydroxide; 3 A molecular sieve; potassium acetate; sodium tris(acetoxy)borohydride; sodium cyanoborohydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In methanol; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm9800907

Reference yield:

: (S)-2-((2S,3S)-2-tert-Butoxycarbonylamino-3-methyl-pentylamino)-3-phenyl-propionic acid

: 150350-34-8
N-[2(S)-(2(R)-t-butoxycarbonylamino-3-triphenylmethylmercaptopropylamino)-3(S)-methylpentyl]phenylalanyl-methionine methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: HOBt, EDC, Et₃N / dimethylformamide / Ambient temperature

2: HCl (gas) / ethyl acetate / -25 °C

3: NaCNBH₃, KOAc, 3A molecular sieves / methanol / Ambient temperature

With hydrogenchloride; 3 A molecular sieve; potassium acetate; sodium cyanoborohydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm9800907