2-cyano-1-(4-fluorophenyl)-3-(1-hydroxy-2,2,5,5-tetramethylpyrrolidin-3-yl)guanidine oxy radical

Base Information

• Chemical Name: 2-cyano-1-(4-fluorophenyl)-3-(1-hydroxy-2,2,5,5-tetramethylpyrrolidin-3-yl)guanidine oxy radical
• CAS No.: 1380677-17-7
• Molecular Formula: C₁₆H₂₁FN₅O
• Molecular Weight: 318.374
• Mol file: 1380677-17-7.mol

Synonyms:2-cyano-1-(4-fluorophenyl)-3-(1-hydroxy-2,2,5,5-tetramethylpyrrolidin-3-yl)guanidine oxy radical

Chemical Property of 2-cyano-1-(4-fluorophenyl)-3-(1-hydroxy-2,2,5,5-tetramethylpyrrolidin-3-yl)guanidine oxy radical

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-cyano-1-(4-fluorophenyl)-3-(1-hydroxy-2,2,5,5-tetramethylpyrrolidin-3-yl)guanidine oxy radical

There total 2 articles about 2-cyano-1-(4-fluorophenyl)-3-(1-hydroxy-2,2,5,5-tetramethylpyrrolidin-3-yl)guanidine oxy radical which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

CYANAMID (420-04-2) + {2,2,5,5-tetramethyl-3-[(4-fluorophenyl-1-ylcarbamothioyl)amino]pyrrolidin-1-yl}oxidanyl (1380677-77-9) → 2-cyano-1-(4-fluorophenyl)-3-(1-hydroxy-2,2,5,5-tetramethylpyrrolidin-3-yl)guanidine oxy radical (1380677-17-7)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In acetonitrile; at 80 ℃; for 24h;

Reference yield:

2,2,5,5-tetramethyl-3-aminopyrrolidine-1-oxyl (34272-83-8) + 4-fluorophenyl isothiocyanate (1544-68-9) → 2-cyano-1-(4-fluorophenyl)-3-(1-hydroxy-2,2,5,5-tetramethylpyrrolidin-3-yl)guanidine oxy radical (1380677-17-7)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 3 h / 20 °C

2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 24 h / 80 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; acetonitrile;

upstream raw materials:

CYANAMID

{2,2,5,5-tetramethyl-3-[(4-fluorophenyl-1-ylcarbamothioyl)amino]pyrrolidin-1-yl}oxidanyl

2,2,5,5-tetramethyl-3-aminopyrrolidine-1-oxyl

4-fluorophenyl isothiocyanate

Refernces