2-(3'-thienyl)ethyl chloride

Base Information

• Chemical Name: 2-(3'-thienyl)ethyl chloride
• CAS No.: 7136-58-5
• Molecular Formula: C₆H₇ClS
• Molecular Weight: 146.641
• Mol file: 7136-58-5.mol

Synonyms:2-(3'-thienyl)ethyl chloride

Chemical Property of 2-(3'-thienyl)ethyl chloride

Chemical Property:

Purity/Quality:

>98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3'-thienyl)ethyl chloride

There total 1 articles about 2-(3'-thienyl)ethyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

→ 7-methyl-6,7-dihydrothieno[2,3-c]pyridine (178308-07-1) + 2-(3'-thienyl)ethyl chloride (7136-58-5)

Guidance literature:

Reference yield: 85.0%

2-(3'-thienyl)ethyl chloride (7136-58-5) + tert-Butylphenylphosphine oxide (98976-30-8,57956-51-1,6057-79-0,82945-11-7) → tert-butylphenyl-2-(3-thiophenyl)ethylphosphine oxide (1445236-19-0)

Guidance literature:

tert-Butylphenylphosphine oxide; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 1h; Inert atmosphere;

2-(3'-thienyl)ethyl chloride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 24h;

DOI:10.1080/10426507.2012.740107

Reference yield:

2-(3'-thienyl)ethyl chloride (7136-58-5) → 3-(3-thienyl)-propyl alcohol (20905-98-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / 18-crown-6 / acetonitrile / 19 h / Heating

2: 98 percent / KOH, H₂O / ethanol / Heating

3: 92 percent / LiAlH₄ / diethyl ether / 3 h / Heating

With potassium hydroxide; lithium aluminium tetrahydride; 18-crown-6 ether; water; In diethyl ether; ethanol; acetonitrile;

DOI:10.1021/j100124a045

Downstream raw materials:

7-methyl-4,5-dihydro-thieno[2,3-c]pyridine

7-methyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine

3-(3-thienyl)-propyl alcohol

tert-butylphenyl-2-(3-thiophenyl)ethylphosphine oxide

Refernces