1-[(4-{3-[1-(2-ethoxyethyl)-1H-1,2,3-triazole-4-yl]propoxy}-3-methoxyphenyl)methyl]-4-(2-methoxyphenyl)piperazine

Base Information

Chemical Name:1-[(4-{3-[1-(2-ethoxyethyl)-1H-1,2,3-triazole-4-yl]propoxy}-3-methoxyphenyl)methyl]-4-(2-methoxyphenyl)piperazine
CAS No.:1311157-71-7
Molecular Formula:C₂₈H₃₉N₅O₄
Molecular Weight:509.649
Hs Code.:

Synonyms:1-[(4-{3-[1-(2-ethoxyethyl)-1H-1,2,3-triazole-4-yl]propoxy}-3-methoxyphenyl)methyl]-4-(2-methoxyphenyl)piperazine

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Chemical Property of 1-[(4-{3-[1-(2-ethoxyethyl)-1H-1,2,3-triazole-4-yl]propoxy}-3-methoxyphenyl)methyl]-4-(2-methoxyphenyl)piperazine

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Technology Process of 1-[(4-{3-[1-(2-ethoxyethyl)-1H-1,2,3-triazole-4-yl]propoxy}-3-methoxyphenyl)methyl]-4-(2-methoxyphenyl)piperazine

There total 4 articles about 1-[(4-{3-[1-(2-ethoxyethyl)-1H-1,2,3-triazole-4-yl]propoxy}-3-methoxyphenyl)methyl]-4-(2-methoxyphenyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 62634-47-3
β-Ethoxyethyl azide

: 1311157-67-1
1-{[3-methoxy-4-(pent-4-yn-1-yloxy)phenyl]methyl}-4-(2-methoxyphenyl)piperazine

: 1311157-71-7
1-[(4-{3-[1-(2-ethoxyethyl)-1H-1,2,3-triazole-4-yl]propoxy}-3-methoxyphenyl)methyl]-4-(2-methoxyphenyl)piperazine

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; In methanol; diethyl ether; dichloromethane; at 20 ℃;
DOI:10.1021/jm2004859

Reference yield:

: 14267-92-6
1-chloro-4-pentyne

: 1311157-71-7
1-[(4-{3-[1-(2-ethoxyethyl)-1H-1,2,3-triazole-4-yl]propoxy}-3-methoxyphenyl)methyl]-4-(2-methoxyphenyl)piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; potassium iodide / acetonitrile / 16 h / Reflux

2: sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 20 °C / Inert atmosphere

3: sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; copper(ll) sulfate pentahydrate / methanol; diethyl ether; dichloromethane / 20 °C

With copper(ll) sulfate pentahydrate; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; sodium tris(acetoxy)borohydride; potassium carbonate; potassium iodide; In methanol; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1021/jm2004859

Reference yield:

: 1001289-60-6
3-methoxy-4-(pent-4-yn-1-yloxy)benzaldehyde

: 1311157-71-7
1-[(4-{3-[1-(2-ethoxyethyl)-1H-1,2,3-triazole-4-yl]propoxy}-3-methoxyphenyl)methyl]-4-(2-methoxyphenyl)piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 20 °C / Inert atmosphere

2: sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; copper(ll) sulfate pentahydrate / methanol; diethyl ether; dichloromethane / 20 °C

With copper(ll) sulfate pentahydrate; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; sodium tris(acetoxy)borohydride; In methanol; diethyl ether; dichloromethane;
DOI:10.1021/jm2004859